I-10-DAB Semi-Synthetic Paclitaxel: Indima ebalulekileyo kwiNqanaba lokuSebenza kweZiyobisi

I-Paclitaxel lichiza eliyimfuneko elisetyenziswa kakhulu kunyango lomhlaza, kodwa imithombo yalo yendalo ilinganiselwe.Ukuze kuhlangatyezwane nemfuno ye-paclitaxel kwimarike yamayeza, izazinzulu zenze uphando olubanzi, kunye neendlela ze-semi-synthetic zibe yindlela ebalulekileyo yokuvelisa.Eli nqaku liza kwazisa inkqubo ye-semi-synthesizing paclitaxel esuka kwi-10-deacetylbaccatin III (10-DAB) kwaye igxininise ukubaluleka kwayo kwintsimi ye-drug synthesis.

I-Paclitaxel, ekuqaleni yayizimele kwixolo lomthi we-Pacific yew, idume ngeempawu zayo ezibalaseleyo zokulwa nomhlaza.Nangona kunjalo, i-yew yePasifiki sisixhobo sendalo esinesiphelo, esinganelanga ukuhlangabezana nemfuno yezonyango yanamhlanje ye-paclitaxel.Ukuphuhliswa kweendlela ze-semi-synthetic zenze imveliso enkulu ye-paclitaxel inokwenzeka, kunye ne-10-deacetylbaccatin III ibe yinto ebalulekileyo ephakathi.

Ukulungiswa kwe-10-DAB kwi-Semi-Synthetic Paclitaxel:

I-10-DAB ingundoqo ophakathi kwindlela ye-semi-synthetic eya kwi-paclitaxel kwaye ifuna amanyathelo amaninzi okulungiselela kwayo.Ngokuqhelekileyo, i-synthesis ye-10-DAB iqala nge-precursor yendalo ye-paclitaxel, taxuyunnanine C, ephuma kwi-baccatin III.I-Baccatin III iqale i-deacetylated ukuze ivelise i-10-deacetylbaccatin III.Emva koko, i-10-deacetylbaccatin III ifumana iimpendulo ezininzi, kubandakanywa i-hydrogenation, i-substitution, i-epoxidation, i-hydrolysis, kunye nokunye, ekugqibeleni iguqule kwi-10-DAB.

Usetyenziso lwe-10-DAB kwi-Semi-Synthetic Paclitaxel:

I-synthesis ye-10-DAB ivule indlela entsha ye-semi-synthesis ye-paclitaxel, ebonelela ngokuzinzileyo kwimveliso yeziyobisi.I-Paclitaxel liyeza elibanzi le-anticancer elisetyenziswa kunyango lweentlobo ezahlukeneyo zomhlaza, kubandakanya i-ovarian, ibele kunye nomhlaza wemiphunga.Indlela ye-semi-synthetic yehlisa ixabiso lemveliso yamachiza, yenza olu khetho lubalulekileyo lonyango lufikeleleke ngakumbi kwizigulana.

Isiphelo:

Indlela ye-semi-synthesizing paclitaxel esuka kwi-10-DAB iphumelele impumelelo ebalulekileyo kwintsimi ye-chiza synthesis.Ayijonganga kuphela umba wemithombo yendalo enyiniweyo ye-paclitaxel kodwa iphakamisa ukusebenza kakuhle kwemveliso kunye nokuzinza.Le teknoloji imele isiganeko esibalulekileyo ekuvelisweni kwamachiza e-anticancer kwaye ibambe isithembiso senkqubela phambili kwicandelo lezonyango ukulwa nezifo ezinobungozi ezifana nomhlaza.Kwixesha elizayo, abaphandi baya kuqhubeka nokucoca iindlela zokudibanisa ukuphucula ukusebenza kakuhle kunye nokunciphisa iindleko, ekugqibeleni bazuze uluhlu olubanzi lwezigulane.

Qaphela: Iingenelo ezinokuba luncedo kunye nokusetyenziswa okukhankanywe kweli nqaku kusekelwe kuncwadi olufumaneka esidlangalaleni.

Ukufunda Ngakumbi: Yunnan Hande Biotech Co., Ltd., kunye neminyaka engama-26 yokugxila kwimveliso ye-paclitaxel, ngumvelisi ozimeleyo ovunyiweyo kwihlabathi jikelele wezityalo ezikhutshiweyo ze-anticancer drug paclitaxel izithako ezisebenzayo zamachiza, ezivunyiweyo yi-arhente ezilawulayo ezifana ne-US FDA, i-EDQM yaseYurophu. , Australia TGA, China CFDA, India, Japan, kunye nabanye.I-Yunnan Hande Paclitaxel, ekhoyo kwisitokhwe, ithengiswa ngokuthe ngqo ngumenzi.Nceda uzive ukhululekile ukufowunela imibuzo apha +86 18187887160 (WhatsApp).