Yenziwa njani iSemi-synthetic paclitaxel?

I-Paclitaxel, ichiza lendalo elichasayo lomhlaza, litsalwa ikakhulu kwi-Taxus chinensis.Isetyenziswe ngokubanzi kunyango lomhlaza wamabele, umhlaza wesibeleko, kunye nomhlaza wentloko kunye nentamo kunye nomhlaza wemiphunga ngokwezonyango.I-Paclitaxel yahlulwe ngokwendalo.paclitaxelkwayeI-semi-synthetic paclitaxel.Ngezantsi, makhe sijonge indlela i-Semi-synthetic paclitaxel eyenziwa ngayo.

Kuba i-paclitaxel yendalo itsalwa kwi-Taxus chinensis enemithombo embalwa, kwaye umjikelo wokukhula we-Taxus chinensis yendalo mde, kuphela malunga ne-13.6kg bark enokukhipha i-1g ye-paclitaxel, kwaye ithatha i-3 ukuya kwi-12 yemithi ye-taxus enembali engaphezu kweminyaka eyi-100. ukunyanga isigulana somhlaza we-ovarian, ukunqongophala kwexesha elide lokubonelela kunye nexabiso eliphezulu kwenza iteknoloji ye-artificial synthesis ye-paclitaxel ikhule ngokukhawuleza.

Njengento ethatyathwe kwizityalo zendalo, i-paclitaxel inolwakhiwo oluntsonkothileyo. Nangona kunjalo, ukulungisa ukunqongophala kwezinto ezikrwada, iikhemisti ezivela kwihlabathi liphela zifunda ukuhlanganiswa kwe-paclitaxel. De i-chemist yaseFransi yahlula into ebizwa ngokuba10-DABukusuka kumagqabi eBritish Taxus chinensis,isakhiwo sayo sasifana kakhulu neso sepaclitaxel,kwaye umxholo wayo wawuphezulu.Amagqabi ayehlaziyeka ngakumbi kunexolo kunye namasebe,kwaye ayenomonakalo omncinci kwiTaxus chinensis.

Ngokusebenzisa iinzame ezingapheliyo zenzululwazi, indlela yeI-semi-synthetic paclitaxelyaphuhliswa ekugqibeleni, kwaye akusekho mfuneko yokugawula i-Taxus chinensis ukuyikhupha. Emva koko, ngokufunda ubume be-paclitaxel, amanye amachiza ekhemikhali afana ne-docetaxel kunye ne-albumin paclitaxel aphuhliswa, ezisa amayeza onyango ngakumbi kwizigulana ezinomhlaza.

Ingcaciso:Ukusebenza okunokwenzeka kunye nokusetyenziswa okukhankanywe kweli nqaku zonke zivela kuncwadi olufumaneka esidlangalaleni.

Ufundo olwandisiweyo:I-Hande Bio-tech ibandakanyeka ikakhulu ekutsalweni nasekuphuhliseni i-taxanes.Imveliso yayo engundoqo yi-paclitaxel yendalo, i-10-DAB Semi-synthetic paclitaxel, i-10-DABIII, i-docetaxel, i-cabataxel, njl. Ukuba ufuna ukwazi nge-paclitaxel APIs esekwe, nceda uzive ukhululekile ukuba uqhagamshelane nathi.