I-Paclitaxel yimveliso yendalo eyodwa kwaye ihlanjululwe kwixolo, iingcambu zemithi, amagqabi, amahlumela kunye nezithole zomthi we-redbud, kunye nomxholo ophezulu kwi-bark.Paclitaxelisetyenziswa ikakhulu kumhlaza wamaqanda namabele, kodwa iyasebenza nakumhlaza wemiphunga, umhlaza wesikhumba, imelanoma, umhlaza wentloko kunye nentamo, i-lymphoma kunye nethumba lobuchopho.
I-Paclitaxel isetyenziswa ngokubanzi kunyango lomhlaza wemiphunga, umhlaza wamabele, umhlaza we-ovarian, umhlaza wentloko kunye nentamo, umhlaza wesisu kunye nezinye izicubu ezinobungozi. ,indibano ye-microtubule kunye nokuthintela ukuchithwa kwe-depolymerization, ngaloo ndlela kuzinzisa ii-microtubules kunye nokuthintela i-mitosis kunye nokubangela i-apoptosis yeeseli zomhlaza, ngaloo ndlela kunqande ngokufanelekileyo ukwanda kweeseli zomhlaza kunye nokudlala indima echasene nomhlaza.
Sele kuyiminyaka engama-30 ukususela ngokopaclitaxelyathengiswa ngo-1992.Ngenxa yokusebenza kwayo okuchanekileyo, izibonakaliso ezibanzi kunye nemfuno enkulu yeklinikhi, uphando kunye nophuhliso lweendlela eziphuculweyo zedosi ye-paclitaxel iqhubekile, kwaye iifom zedosi ye-paclitaxel ezithengisiweyo ziquka inaliti eqhelekileyo ye-paclitaxel,paclitaxelI-liposome kunye ne-albumin paclitaxel.Imveliso ye-paclitaxel ngoku zezona arhente zeekhemikhali ezikwinqanaba eliphezulu e-China ngokwexabiso lentengiso, kwaye zikwayeyona inkulu ngokwemali yokuthengisa kwicandelo lamachiza e-antitumor.
Qaphela:Ukusebenza okunokwenzeka kunye nokusetyenziswa okuchazwe kweli nqaku kuncwadi olupapashiweyo.
Ixesha lokuposa: Jun-13-2023