Umatshini wokulwa nomhlaza wePaclitaxel.Yintoni oyaziyo?

I-Paclitaxel lichiza elichasayo lomhlaza elisetyenziselwa ukunyanga iintlobo ezininzi zomhlaza. Yaqala yatsalwa kwixolo lomthi we-Pacific yew (Taxus pacifica) kwaye kamva yaveliswa ngeendlela zokwenziwa.Paclitaxelukwiklasi yamachiza abizwa ngokuba yi-microtubule stabilizers.

Indlela yokulwa nomhlaza yepaclitaxelibandakanya iinkalo ezininzi, ingakumbi ezi zilandelayo:

I-1.Ukunyuka kokuzinza kwe-microtubule: I-Paclitaxel ikhusela ukuzinza okuguquguqukayo okuqhelekileyo kwee-microtubules ngokuzibophelela kwi-tubulin, eyinxalenye ye-cytoskeleton.Oku kubangela ukuba i-microtubules ingaphumeleli ukudiliza kunye nokulungelelanisa, ukuthintela ukuhlukana kunye nokukhula kweeseli. Inqaku eliphambili lomhlaza, ngoko ke ukuthintela ukwahlukana kweeseli ngokuzinzisa i-microtubules yeyona nto iphambili yokulwa nomhlaza wepaclitaxel.

I-2.I-Cell cycle arrest: I-Paclitaxel inokubangela ukubanjwa kwe-cell cycle, okubangela ukuba iiseli zomhlaza zigxininise kwisigaba esithile somjikelezo weseli, ngokuqhelekileyo i-mitosis.Oku kunceda ukucotha ukukhula kunye nokwahlulwa kweeseli zomhlaza.

I-3.Ikhuthaza i-apoptosis: I-Paclitaxel inokuthintela ukuphuhliswa komhlaza ngokubangela ukuba iiseli zomhlaza ezonakalisiweyo okanye ezingaqhelekanga zingene kwi-apoptosis (i-programmed cell death). Le yinkqubo yokufa kweeseli zendalo ezinceda ukususa iiseli ezingaqhelekanga.

4.Anti-angiogenesis:Paclitaxelinokuthintela ukwakheka kwemithambo yegazi emitsha ejikeleze iiseli zomhlaza, eyimfuneko ekukhuleni kwethumba kunye nokusasazeka.Ngokuthintela ukwakheka kwemithambo yegazi emitsha, inokunciphisa unikezelo lwegazi kwithumba, ngaloo ndlela ithintele ukukhula kwethumba.

Ngokubanzi, i-paclitaxel lichiza eliphazamisa ukukhula kunye nokwahlukana kweeseli zomhlaza, ezisebenza kwiiseli zomhlaza ngeendlela ezahlukeneyo, kwaye ke ngoko isetyenziswa ngokubanzi kwiintlobo ezininzi zonyango lomhlaza.

Qaphela:Iinzuzo ezinokubakho kunye nezicelo ezichazwe kweli nqaku zithathwe kuncwadi olupapashiweyo.

I-Yunnan Hande Biotechnology Co., Ltd. iye yagxila kwimveliso yepaclitaxeliminyaka engama-26, kwaye ngumvelisi ozimeleyo wezityalo ezikhutshwe kwi-anti-cancer drug paclitaxel API ezivunywe yi-United States FDA, European EDQM, Australia TGA, China CFDA, India, Japan kunye nezinye ii-arhente ezilawulayo zesizwe.Yunnan Hande paclitaxel, indawo yokubonelela , ukuthengiswa ngokuthe ngqo kwifektri, wamkelekile ukubuza, 18187887160 (WhatsApp inombolo efanayo)