I-Paclitaxel lichiza elenzekayo ngokwendalo elinomsebenzi obalulekileyo wokuchasana nomhlaza, elisetyenziswa ngokubanzi kunyango lwee-cancer ezahlukeneyo.Ngokonyuka kwemfuno yeklinikhi, inkqubo yokuvelisa kunye nobuchwepheshe bomhlaza.Paclitaxel APIzikwaqhuba ngokuqhubekayo.Eli nqaku liza kwazisa inkqubo yokuvelisa kunye nobuchwepheshe be-Paclitaxel API ngokweenkcukacha.
I.Umthombo kunye nokutsalwa kwePaclitaxel
I-Paclitaxel ithathwa kakhulu kwi-Taxus brevifolia, i-Taxus cuspidata, i-Taxus wallichiana kunye nezinye iintlobo ze-Taxus.Iindlela zokukhutshwa zibandakanya i-solvent extraction, i-ultrasonic extraction, i-microwave extraction, njl. kunye nokusetyenziswa kwe-solvent enkulu.Ngoko, kwiminyaka yakutshanje, abaphandi bebesoloko bezama iindlela ezintsha zokukhupha, ezifana ne-enzyme hydrolysis, i-supercritical fluid extraction, njl., ukuphucula ukusebenza kakuhle kunye nokucoceka.
II.Inkqubo yokuveliswa kwePaclitaxel
Indlela yokuBilisa yokuveliswa kwePaclitaxel
Kwiminyaka yakutshanje, iindlela zokubilisa ziye zaphononongwa ngokubanzi ukuveliswa kwePaclitaxel.Le ndlela isebenzisa iteknoloji yokuvutshelwa kwemicrobial ukuvelisa iPaclitaxel ngokulima nokubilisa iiseli zeTaxus.Indlela ineengenelo ezifana nomjikelo omfutshane wemveliso, isivuno esikhulu, kunye nococeko oluphezulu. , idinga ukulungelelaniswa kweemeko zokuvutshelwa kunye nokuhlolwa kweentlobo eziphezulu zokuvelisa ukuphucula ukuveliswa kwemveliso kunye nokunciphisa iindleko.
Indlela ye-Chemical synthesis yokuveliswa kwePaclitaxel
I-Chemical synthesis enye indlela ebalulekileyo yokuvelisa i-Paclitaxel.Le ndlela isebenzisa iteknoloji ye-organic synthesis ukuze idibanise i-Paclitaxel ngokusebenzisa iindlela ze-chemical synthesis.Nangona le ndlela ineenzuzo ezifana nemveliso enkulu kunye nokucoceka okuphezulu, inezinto ezingalunganga ezifana neendlela ezide zokwenziwa kunye iindleko eziphezulu, ezinciphisa ukusetyenziswa kwayo okusebenzayo.
Ukudibanisa ukutsalwa kwendalo kunye nokuhlanganiswa kweekhemikhali kwinkqubo yokuvelisa
Ukoyisa imida yeendlela zokuvelisa enye, abaphandi baphonononga indibaniselwano yokutsalwa kwendalo kunye nokuhlanganiswa kweekhemikhali kwinkqubo yokuvelisa. iteknoloji.Le ndlela idibanisa iingenelo zokutsalwa kwendalo kunye nokuhlanganiswa kweekhemikhali, iphucula ukusebenza kakuhle kwemveliso kunye nokucoceka, kwaye inciphisa iindleko zemveliso.
III.Imingeni kunye nezikhokelo zoPhuculo kwiTekhnoloji yoMveliso wePaclitaxel
Ukuphucula ukusebenza kakuhle kokutsalwa kunye nokucoceka: Ukuphuhlisa iindlela zokutsalwa ezisebenzayo kunye nokusingqongileyo kunye nobuchwepheshe, ezifana nezinyibilikisi ezintsha, i-enzymes edibeneyo, njl., Ukuphucula ukusebenza kakuhle kunye nokucoceka kwePaclitaxel.
Ukuphucula iimeko zokuvundisa kunye nokuhlola iintlobo ezivelisa kakhulu: Ukuphucula iimeko zokuvutshelwa (ezifana nokubunjwa okuphakathi, ubushushu, ixabiso le-pH, njl. njl.) kunye nokuhlola iintlobo ezivelisa kakhulu ukunyusa isivuno kunye nokucoceka kwemveliso yePaclitaxel esekelwe kwi-fermentation.
Ukunciphisa iindleko zemveliso: Ukuphuhlisa izinto ezintsha eziluhlaza, ukuphucula iinkqubo zokuvelisa, kunye nokuphumeza imveliso enkulu ukunciphisa iindleko zemveliso yePaclitaxel kunye nokuphucula ukukhuphisana kwayo kwimarike.
Ukomeleza ulawulo lomgangatho: Ukuseka inkqubo yolawulo lomgangatho olubanzi ukulawula ngokungqongqo umgangatho wezinto ezikrwada, iinkqubo zemveliso, kunye neemveliso ngolawulo olungqongqo lomgangatho kunye novavanyo lohlalutyo lokuqinisekisa umgangatho wemveliso kunye nokhuseleko.
Ukuphuhliswa kweendlela ezintsha zokuqulunqa: Ukuphuhliswa kweendlela ezintsha (ezifana ne-nanomaterials, i-liposome formulations, njl.) ukuphucula i-bioavailability kunye nokusebenza kakuhle kwe-Paclitaxel kwi-vivo ngokusekelwe kwiintsilelo zesicelo seklinikhi.
Ukwandisa imimandla yesicelo: Ukwandisa ngakumbi imimandla yesicelo sePaclitaxel ngaphaya kwonyango lomhlaza (ezifana ne-anti-inflammatory, antioxidant effects), ukusebenzisa iziphumo zayo ezibanzi ze-pharmacological kunye nexabiso lesicelo.
IV.Isiphelo kunye neZibonelelo
Ngenkqubela phambili eqhubekayo yesayensi kunye netekhnoloji kunye nokwanda kwemfuno yekliniki yePaclitaxel API, inkqubo yokuvelisa kunye nobuchwepheshe be-Paclitaxel API nazo ziqhubeka ziphuhlisa. Kwixesha elizayo, abaphandi baya kuqhubeka behlola iinkqubo ezintsha zemveliso kunye neendlela zobugcisa zokuphucula ukusebenza kakuhle kwemveliso yePaclitaxel, ukunciphisa iindleko zokuvelisa, ukwandisa imimandla yesicelo, kwaye wenze igalelo elikhulu. kwimpilo yabantu.
Qaphela:Ukusebenza okunokwenzeka kunye nezicelo ezikhankanywe kweli nqaku zithathwe kuncwadi olupapashwe esidlangalaleni.
Ixesha lokuposa: Dec-13-2023