I-Paclitaxel, i-compound yendalo enomsebenzi onamandla wokulwa nomhlaza, ibe yinxalenye ebalulekileyo yonyango lomhlaza.Into ebizwa ngokuba yi-taxol, iphuma kwixolo lomthi we-yew kwaye yi-alkaloid ye-diterpenoid. Kule minyaka imbalwa idlulileyo,paclitaxelibonise ukusebenza okubonakalayo kunyango lweentlobo ezahlukeneyo zomhlaza, kubandakanywa ibele, i-ovarian, kunye nomhlaza wentloko kunye nentamo kunye nemiphunga.
Okokuqala, umsebenzi wokulwa nomhlaza we-paclitaxel yeyona nto iphambili ye-pharmacological properties.Inokulawula ngokufanelekileyo ukukhula kweeseli zethumba kwaye ithintele ukusasazeka kunye ne-metastasis yamathumba ngokuthintela inkqubo ye-unhelix ye-DNA kwaye ngaloo ndlela inqanda ukuphindaphinda kwe-DNA. Ifumaneka ikakhulu ngokuzinzisa i-tubulin, ukuthintela i-mitosis kunye nokubangela i-apoptosis.
Kwinkqubo yonyango, i-paclitaxel isetyenziswe ngokubanzi kunyango lomhlaza wamabele. Ngokudityaniswa, i-paclitaxel inokuphucula kakhulu ukusinda kwesigulana, ukunciphisa ukuphindaphinda kwethumba, kunye nokuphucula umgangatho wobomi bezigulane. Ngokuthintela ukuphindaphindwa kwe-DNA yeeseli ze-tumor kunye nokunyanzeliswa kwe-apoptosis, i-paclitaxel inokulawula ngokufanelekileyo ukukhula kwethumba kunye nokwandisa ixesha lokusinda kwezigulana.
Ukongeza kumhlaza webele kunye ne-ovarian,paclitaxelikwabonise iziphumo ezilungileyo kunyango lwezinye iintloko kunye nomhlaza wentamo kunye nomhlaza wemiphunga.Kolu nyango lwethumba, i-paclitaxel isoloko isetyenziswa ngokudityaniswa namanye amachiza e-anticancer ukufikelela kwisiphumo esisebenzayo sonyango.
Nangona kunjalo, nangona impembelelo yonyango ye-paclitaxel ibalulekile, kunokubakho ukusabela okubi ngexesha lokusetyenziswa.Izigulane zinokufumana iimpawu ezifana nokunyanzeliswa komongo wethambo, ukukhubazeka kwesibindi kunye nezintso, ukusabela kwesisu, i-allergies, okanye i-vasculitis emva kokusetyenziswa kwe-paclitaxel. xa usebenzisa i-paclitaxel, kuyimfuneko ukujonga ngononophelo imeko yokusabela kwezigulana, kunye nongenelelo olusexesheni lweklinikhi ukunciphisa ukusabela okubi.
Nje,paclitaxelidlale indima ebalulekileyo kunyango lomhlaza kwaye iyasebenza kakhulu ngokuchasene neentlobo ezahlukeneyo zamathumba anobungozi.Nangona kukho ezinye iziphumo ezibi, ngokukhokelwa ngamayeza afanelekileyo kunye nokuhlolwa kweklinikhi, inokunciphisa ngempumelelo ingozi enokubakho kwaye yandise isiphumo sayo sonyango.Ngokuqhubekayo ngokuqhubekayo. Inkqubela phambili yesayensi kunye nobuchwepheshe kunye nokuqonda okunzulu kweziphumo ze-pharmacological ze-paclitaxel ngabaphandi, sinesizathu sokukholelwa ukuba kuya kubakho amachiza amatsha kunye asebenzayo kwi-paclitaxel kwixesha elizayo, ukuzisa iindlela zonyango ezininzi kunye nethemba kwizigulane ezinomhlaza.
Qaphela:Iinzuzo ezinokubakho kunye nezicelo ezichazwe kweli nqaku zithathwe kuncwadi olupapashiweyo.
Ixesha lokuposa: Nov-14-2023