Artemisia annua extract Artemisinin 98% Antimalarial izityalo ekrwada imathiriyeli

Ulwazi ngeMveliso

Isicatshulwa se-Artemisia annua sisicatshulwa sengca esomileyo esipheleleyo semifuno yonyaka i-Artemisia annua kunye ne-Artemisia annua;Ngokukodwa iqulethe i-flavonoids, i-coumarins, i-terpenes, i-phenylpropionic acid, ioli eguquguqukayo kunye nezinye i-artemisinin;Ineempembelelo ze-pharmacological ezifana ne-antimalarial, i-antibacterial, i-antiviral, i-anti-inflammatory, i-antipyretic kunye ne-analgesic, i-anti schistosomiasis kunye nezinye i-parasites, i-immunity, inhibition ye-tumor kunye ne-cardiovascular system;Ngokweklinikhi, idla ngokusetyenziswa kunyango lwesifo seengcongconi, yin ukusilela umkhuhlane, ubushushu bamathambo, ubushushu ububi, ibronchitis engapheliyo, i-discoid lupus erythematosus, i-lichen planus yomlomo, i-dermatomycosis, i-neurodermatitis, i-pruritus yolusu, urhudo lwe-infantile ekwindla, i-epistaxis kunye nezinye iimpawu. .
1, Amacandelo aphambili
Isicatshulwa seArtemisia annua ikakhulu sibandakanya i-flavonoids, i-coumarins, i-terpenes, i-phenylpropionic acid, ioli eguqukayo kunye nabanye.
2. Umsebenzi
1. Impembelelo ye-Antimalarial
Iimvavanyo zibonakalise ukuba indawo engathathi hlangothi ekhutshwe yi-ether ye-Artemisia annua kunye nesicatshulwa sayo sotywala esixutyiweyo sineziphumo ezibalulekileyo zokulwa nesifo seengcongconi kwimalariya yempuku, i-malaria yenkawu kunye nesifo seengcongconi.Kwimifuniselo ye-vivo yabonisa ukuba i-artemisinin inesiphumo sokubulala kwisigaba se-intracellular se-Plasmodium falciparum, kodwa ayizange ibe nampembelelo kwisigaba esingaphandle kwe-extracellular kunye ne-prophase ye-Plasmodium falciparum.Inokuthintela ngokukhawuleza ukuvuthwa kwePlasmodium.Imifuniselo ye-in vitro ibonise ukuba i-artemisinin inokunqanda ngokubonakalayo ukukhula kweeclones zePlasmodium falciparum kwaye ibenesiphumo sokubulala ngokuthe ngqo.
2. Imiphumo ye-Antibacterial kunye ne-antiviral
I-Artemisia annua decoction inempembelelo enamandla yokuthintela kwi-Staphylococcus epidermidis, catarrhalis, anthrax kunye ne-diphtheria.Kwakhona kunempembelelo ethile yokuthintela kwi-Staphylococcus aureus, i-Pseudomonas aeruginosa, i-dysentery, isifo sephepha kunye nezinye ii-bacilli.Ioli ye-Artemisia annua eguquguqukayo inefuthe elithintelayo kuzo zonke iidermatophytes kugxininiso lwe-0% kunye ne-25%, kunye nesiphumo se-bactericidal kuzo zonke iidermatophytes kwi-concentration ye-1%.I-Artemisinin inesiphumo sentsholongwane echasene nomkhuhlane.I-sodium artesunate ineziphumo ezithile zokulwa ne-antibacterial kwi-Staphylococcus aureus, i-Shigella flexneri, i-Escherichia coli, i-Catacoccus, i-paratyphoid A kunye ne-B.
3. I-Anti inflammatory, antipyretic kunye ne-analgesic effects
I-Scopolamine equlethwe kwi-Artemisia annua extract ine-anti-inflammatory effect.Kuye kwaxelwa ukuba indawo enyibilikayo yamanzi ye-artemisinin ekhutshwe kwi-Artemisia annua inesiphumo se-antipyretic kulingo lwezonyango.Kwakhona kuye kwaxelwa ukuba i-artemisinin ayinayo i-antipyretic effect.Inaliti ye-Artemisia annua elungiswe yi-distillation inefuthe elicacileyo le-antipyretic kwimivundla ebangelwa lugonyo oluphindwe kathathu lwe-Baibai kunye ne-tetanus.
4. Anti schistosomiasis kunye nezinye izifunxi-gazi
I-Artemisinin, i-artemisinin kunye nezinto eziphuma kuzo zineempembelelo ezichasene neschistosomiasis.Imifuniselo yeempuku yabonisa ukuba i-artemisinin inesiphumo esicacileyo sokubulala kwi-Schistosoma japonicum yabantu abadala.Nangona ixesha lokukhuthaza "ukufuduka kwesibindi" lalicotha, isiphumo sokubulala sasikhawuleza kwaye sicace ngakumbi kwabasetyhini.I-Artesunate kunye ne-artemether zazisebenza kunyango lweempuku kunye nemivundla eyosulelwe yi-Schistosoma japonicum.Nangona kunjalo, i-artemether inokubangela umonakalo ocacileyo kwisibindi somninimzi kwi-dose yonyango.I-Artemisinin kunye nezinto eziphuma kuyo zineempembelelo ezilungileyo ze-insecticidal kunye ne-insecticidal kwi-Clonorchis sinensis.
5. Impembelelo kwi-immune system
I-Artemether inokunciphisa umxholo we-serum IgG kwaye yandise ubunzima be-spleen kwiigundane eziqhelekileyo.Ukunciphisa umxholo we-serum IgG kwinkukhu erythrocyte sensitized iimpuku.I-Artemisinin kunye ne-artemether inokukhuthaza ukwanda kweeseli ze-TS ze-spleen kunye nokuthintela i-IgG.I-Intramuscular artemether nayo yehla i-T, B, Tu kunye ne-tr lymphocytes kwigazi le-peripheral lezinja ze-begle.
6. Iimpembelelo kwi-cardiovascular system
Ukulawulwa komlomo kwenxalenye engathathi hlangothi ekhutshwe kwi-Artemisia annua ether yayingenayo impembelelo ebalulekileyo kwizinga lentliziyo yeekati kunye nezinja, uxinzelelo lwegazi kunye ne-ECG.Uvavanyo lwe-in vitro lwe-perfusion lwentliziyo lwasimahla lubonise ukuba i-artemisinin inokucothisa izinga lokubetha kwentliziyo, inqanda ukuqina kwe-myocardial kunye nokunciphisa ukuhamba kwegazi le-coronary.I-Artemisinin inokuthoba isantya sokubetha kwentliziyo ngokutofa ngomlomo okanye ngomthambo.Kuba i-arrhythmia eyenziwe nge-aconitine kwimivundla, i-artemisinin 20 mg / kg inesiphumo esithile sokulwa noxinzelelo.
7. Impembelelo ye-Antitumor
Iimvavanyo zibonisa ukuba i-artemisinin iyanqanda ukukhula, ukwanda kunye ne-metastasis yeeseli zomhlaza ngeendlela ezahlukeneyo, kwaye ekugqibeleni ibangele i-apoptosis yabo.Kungqiniwe ukuba i-artemisinin inempembelelo yokuthintela kwiiseli ezahlukeneyo zethumba, kunye netyhefu yayo kwiiseli zethishu eqhelekileyo iphantsi kakhulu.
8. Umphumo entliziyweni
I-Artemisinin kwisicatshulwa se-Artemisia annua inokucothisa izinga lokubetha kwentliziyo, inqanda ukuqina kwe-myocardial kunye nokunciphisa ukuhamba kwe-coronary.
3, Indawo yosetyenziso
1. Ishishini lamachiza
2. Ishishini lezithambiso

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