I-Artemisinin 99% ye-Artemisia annua itsalela imathiriyeli ekrwada yamayeza

Ulwazi ngeMveliso

I-Artemisinin liyeza elinesiphumo esihle kunyango lwemalariya.Yi-sesquiterpene lactone eneqela leperoxide ekhutshwe kwi-Artemisia annua.Uneempawu zokusebenza okuphezulu, umphumo okhawulezayo, ukucima ukushisa kunye nokunciphisa ukushisa kwehlobo, ukunciphisa ukushisa okunqongopheleyo, ukubulala i-protozoa kunye ne-toxicity ephantsi.Okwangoku, ukusebenza kwe-artemisinin esekelwe kunyango oludibeneyo (UMTHETHO) kunyango lwemalariya ifikelele ngaphezu kwe-90% kulo lonke ihlabathi.Isetyenziswe kakhulu kunyango lwesifo seengcongconi kwihlabathi liphela.
1. Umsebenzi
1. Ukuchasa isifo seengcongconi
IMalariya (eyaziwa ngokuba yi-pendulum cold and fever disease) sisifo esosulelayo esithwalwa zizinambuzane.Sisifo esosulelayo esibangelwa kukulunywa komzimba womntu owosulelwe yiPlasmodium.Ingabonakala i-hepatosplenomegaly kunye ne-anemia emva kokuhlaselwa okuphindaphindiweyo ixesha elide.I-Artemisinin ibe negalelo kunyango lwemalariya ukusa kumlinganiselo othile.Ibhondi yeperoxide kulwakhiwo lwe-artemisinin i-oxidizing kwaye liqela eliyimfuneko lokuxhathisa isifo seengcongconi.Indlela yokusebenza kukuba iqela elikhululekileyo eliveliswe yi-artemisinin kwi-vivo libophelela kwiprotheni ye-Plasmodium falciparum kwaye itshintshe isakhiwo se-membrane yeseli ye-Plasmodium falciparum.Emva kokuba i-radicals yamahhala idibene neprotheni yePlasmodium, i-membrane ye-bilayer ye-mitochondria iya kudumba kwaye iqhekeke, kwaye ekugqibeleni iwe, ibangele ukutshatyalaliswa kwesakhiwo seseli kunye nomsebenzi wePlasmodium, kwaye i-chromatin kwi-nucleus nayo iya kuchaphazeleka kwabanye. ububanzi.
2. I-Antitumor
Ithumba eliyingozi ngumbulali wokuqala obeka impilo yabantu emngciphekweni.Ukuba ayiphathwa ngexesha, iya kubeka engozini ukhuseleko lobomi.Uvavanyo lwe-in vitro lubonise ukuba idosi ethile ye-artemisinin inokubangela i-apoptosis yeentlobo ezininzi zeeseli zomhlaza, ezinjengeeseli ze-hepatoma, iiseli zomhlaza wamabele, iiseli zomhlaza womlomo wesibeleko njalo njalo, kwaye zithintele kakhulu ukukhula kweeseli zomhlaza.Kufunyaniswa ukuba i-artemisinin inokulawula ukubonakaliswa kwe-cyclin kwiiseli zethumba, ukuphucula umphumo we-CKIs kwaye ikhokelele ekubanjweni komjikelo weseli yethumba;Okanye kukhokelela kwi-apoptosis kunye nokuthintela i-angiogenesis ye-tumor ukumelana nokwenzeka kunye nophuhliso lwe-tumor.I-Artemisinin isetyenziselwa ukunyanga i-leukemia ngokusebenza kwi-membrane yeseli yeeseli ze-leukemia, ukwandisa ukufikeleleka kwenwebu kunye nokutshintsha uxinzelelo lwe-osmotic, okukhokelela ekwandeni koxinzelelo lwe-calcium kwiiseli, ukuze kusebenze i-calpain, yenza inwebu yayo idumbe. kunye nokuqhekeka, ukukhawulezisa ukukhutshwa kwezinto ze-apoptotic kunye nokunyusa isantya se-apoptosis.
3. Unyango lwe-pulmonary hypertension
I-pulmonary hypertension (PAH) yimeko ye-pathophysiological ebonakaliswe ngokulungiswa kwe-pulmonary artery kunye nokunyuka koxinzelelo lwe-pulmonary artery kumda othile.Isenokuba yingxaki okanye i-syndrome.I-Artemisinin isetyenziselwa ukunyanga uxinzelelo lwegazi lwe-pulmonary: inokunciphisa uxinzelelo lwe-pulmonary artery kunye nokuphucula iimpawu kwizigulane ezine-PAH ngokukhulula imithambo yegazi.UZaiman et al.Kwafunyaniswa ukuba i-artemisinin inefuthe elichasayo lokudumba.I-Artemisinin kunye nezinto zayo eziphambili zinokunqanda izinto ezahlukeneyo ezivuthayo, kwaye zinokuthintela ukuveliswa kwe-nitric oxide ngabalamli abavuthayo;I-Artemisinin inempembelelo ye-immunomodulatory;UFeng Yibai kunye nabanye bafumanisa ukuba i-artemisinin inokuthintela ukwanda kweeseli ze-vascular endothelial kunye neeseli ze-vascular smooth muscle, kwaye emva koko zidlala indima ebalulekileyo kunyango lwe-PAH;I-Artemisinin inokuthintela umsebenzi we-matrix metalloproteinases, ngaloo ndlela inqanda ukulungiswa kwe-pulmonary vascular remodeling;I-Artemisinin inokunqanda ukubonakaliswa kweecytokines ezinxulumene ne-PAH kwaye yongeze ngakumbi i-anti vascular remodeling effect ye-artemisinin.
4. Ukulawulwa kwamajoni omzimba
Kufunyaniswe ukuba idosi ye-artemisinin kunye nezinto eziphuma kuyo inokunqanda ngcono i-T lymphocyte mitogen kwaye ibangele ukwanda kwe-lymphocyte ye-spleen yegundane ngaphandle kwe-cytotoxicity.Oku kufunyanisiweyo kunexabiso elilungileyo lesalathiso kunyango lwe-T lymphocyte mediated autoimmune izifo.I-Artemisia annua yeglasi yeviniga inokwandisa ukhuselo lomzimba olungachanekanga kwaye iphucule umsebenzi opheleleyo wokuhambelana kweserum yempuku.I-Dihydroartemisinin inokunqanda ngokuthe ngqo ukwanda kwee-lymphocytes ze-B, ukunciphisa ukukhutshwa kwe-autoantibodies yi-lymphocytes ye-B, ukunciphisa impendulo ye-immune immune, inhibit i-immunity i-humoral kunye nokunciphisa ukusekwa kwe-immune complexes.
5. I-Antifungal
Impembelelo ye-antifungal ye-artemisinin yenza kwakhona i-artemisinin ibonise umsebenzi othile wokulwa neentsholongwane.Uphando luqinisekisile ukuba intsalela yomgubo kunye ne-decoction yamanzi ye-artemisinin ineempembelelo ezinamandla zokulwa ne-anthrax, i-Staphylococcus epidermidis, i-catarrhalis kunye ne-diphtheria, kwaye ibe nemiphumo ethile yokulwa ne-antibacterial kwi-tuberculosis, i-Pseudomonas aeruginosa, i-Staphylococcus aureus kunye ne-dysentery bacilli.
2, Indawo yosetyenziso
I-Artemisia annua isetyenziswa njengechiza lokulwa nemalariya.Isicelo sayo sezonyango sibonakalise ukuba i-artemisinin kunye nezinto eziphuma kuyo zineziphumo ezikhethekileyo kwi-Plasmodium falciparum kunye ne-Plasmodium falciparum, ngakumbi i-Artemisia annua a, enempembelelo enamandla kunamanye amachiza e-artemisinin ekubulaleni ii-clones ze-intracellular ze-Plasmodium falciparum.

IiParameters zeMveliso

IPROFAYILE YEKHAMPANI
Igama lemveliso	Ai-rtemisinin
CAS	63968-64-9
Ifomula yeMichiza	C15H22O5
Birandi	Hkwaye
Mumenzi	Yunnan Hande Bio-Tech Co., Ltd.
Cukuphuma	Kunming,Chayi
Isekiwe	1993
BINGCACISO YEASIC
Izithethantonye	I-3,12-epoxy-12h-pyranol (4,3-j) -1,2-benzodioxepin-10 (3h) -enye, octahydro-3,6,9-tri;artemisiaannual.,extract;huanghuahaosu;octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano(4,3-j) -1,2-benzodioxepin-10(;qinghausau;qinghausu; QHS; I-ARTEMISIN99%
Ulwakhiwo
Ubunzima	282.34
HS Ikhowudi	N / A
UmgangathoSukucaciswa	Inkcazo yeNkampani
CIzaziso	N / A
Isivavanyi	Customized ngokweemfuno zabathengi
Imbonakalo	Ikristale yeacicular engenambala
Indlela yokutsalwa	Artemisia annua
Ubunakho boNyaka	Customized ngokweemfuno zabathengi
Iphakheji	Customized ngokweemfuno zabathengi
Indlela yoVavanyo	N / A
Ulungiselelo	Ezininziuthuthos
PaymentTerms	T/T, D/P, D/A
Oapho	Yamkela uphicotho lwabathengi ngalo lonke ixesha;Ukunceda abathengi ngobhaliso lolawulo.

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