Dihydroartemisinin CAS 81496-82-4 Artemisia annua isicatshulwa

Ulwazi ngeMveliso

I-Dihydroartemisinin iphuma kwi-artemisinin, enesiphumo esinamandla nesikhawulezayo sokubulala kwisigaba se-erythrocytic se-malaria parasites, kwaye inokulawula ngokukhawuleza ukuhlaselwa kwekliniki kunye neempawu.
1, Umthombo wesityalo
I-Dihydroartemisinin yinto ephuma kwi-artemisinin.I-Artemisinin lichiza lokulwa nemalariya elikhutshwe kwi-Artemisia annua.
2. Indima
Isenzo sonyango lwe-dihydroartemisinin siyafana neso se-artemisinin.Isiphumo artemisinin kwi ultrastructure of Plasmodium falciparum kwisigaba erythrocytic ikakhulu ukutshintsha inwebu isakhiwo sayo.Ichiza kuqala lisebenza kwi-membrane ye-vesicle yokutya, inwebu yomphezulu kunye ne-mitochondria, ilandelwa yi-nuclear membrane kunye ne-endoplasmic reticulum.Ukongeza, iphinda ichaphazele i-chromatin kwinucleus.Inokuthi isebenze kwinwebu ye-vesicle yokutya, ithintele inqanaba lokuqala lokutya kwesifo seengcongconi, ibangele iparasite yemalariya ukuba ilambe ngokukhawuleza i-amino acids, yenze ngokukhawuleza i-autophagic vesicles, kwaye iqhubeke iphuma emzimbeni, ilahlekelwe sisixa esikhulu se-amino acid. I-cytoplasm kunye nezondlo, kodwa ingancediswa, ngoko ifa ngokukhawuleza.Imowudi yayo yesenzo ikakhulu ukuphazamisa umsebenzi wePlasmodium surface membrane mitochondria.Ngebhulorho yeperoxide yangaphakathi (i-dioxygen), ilamlwa yintsimbi yasimahla eveliswa emva kokubola kwehemoglobin ukuvelisa iiradicals ezingazinzanga zendalo kunye / okanye ezinye i-electrophilic intermediates, emva koko zenze i-covalent adducts kunye neeproteni ze-malaria parasite, ekhokelela ekubeni ukufa kwesifo seengcongconi.Ukufunyaniswa kwe-tritium ebhalwe i-isoleucine yiPlasmodium falciparum in vitro ekhulileyo nayo ibonise ukuba indlela yayo yokuqala yesenzo ingaba kukuthintela ukuhlanganiswa kweprotheni yePlasmodium.
3, Indawo yosetyenziso
1. Ishishini lamachiza

IiParameters zeMveliso

IPROFAYILE YEKHAMPANI
Igama lemveliso	Dihydroartemisinin
CAS	81496-82-4
Ifomula yeMichiza	C15H24O5
Birandi	Hkwaye
Mumenzi	Yunnan Hande Bio-Tech Co., Ltd.
Cukuphuma	Kunming,Chayi
Isekiwe	1993
BINGCACISO YEASIC
Izithethantonye	(3R,5aS,6R,8aS,9R,12S,12aR)-octahydrogen -3,6,9-trimethyl -3,12-epoxy -12H-pyrane [4,3-j]-1,2-coumaron -10 ( 3H ) utywala; Dihydroartemisinin; Dihxdroarteannui; Dihydroartemisinin USP/EP/BP
Ulwakhiwo
Ubunzima	284.35
HS Ikhowudi	N / A
UmgangathoSukucaciswa	Inkcazo yeNkampani
CIzaziso	N / A
Isivavanyi	Customized ngokweemfuno zabathengi
Imbonakalo	Ikristale emhlophe
Indlela yokutsalwa	Artemisia annua Linn.
Ubunakho boNyaka	Customized ngokweemfuno zabathengi
Iphakheji	Customized ngokweemfuno zabathengi
Indlela yoVavanyo	HPLC
Ulungiselelo	Ezininziuthuthos
PaymentTerms	T/T, D/P, D/A
Oapho	Yamkela uphicotho lwabathengi ngalo lonke ixesha;Ukunceda abathengi ngobhaliso lolawulo.

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