Igqabi le-Mulberry DNJ igqabi le-mulberry likhupha imveliso yezempilo imathiriyeli ekrwada

Ulwazi ngeMveliso

Igqabi leMulberry DNJ yialkaloid yendalo, igama layo lesiTshayina lingu-1-deoxynojirimycin.Yi-enzyme enamandla ye-glucose metabolizing (umzekelo, i-α-Glycosidase) inhibitor inokulibazisa kakhulu inkqubo yokuthotywa kwe-polysaccharide, ukunciphisa ixabiso eliphezulu le-postprandial ye-glucose yegazi kunye nokuzinzisa i-glucose yegazi ngokukhawuleza;Iyeye "inhibitory factor" phakathi kwezinto ezine zokulawula iswekile ze-alfa.
1、 Isiphumo segqabi le-mulberry DNJ
1. Indlela emithathu yokunciphisa iswekile yegazi
Njenge-inhibitor enamandla ye-glucose metabolizing enzymes (umzekelo, i-α- Glucosidase, i-hexokinase, i-glucuronidase kunye ne-glycogen phosphatase, njl.), i-DNJ inokulibazisa kakhulu inkqubo yokuthotywa kwe-polysaccharide, ukunciphisa ixabiso eliphezulu le-postprandial ye-glucose yegazi kunye nokuzinzisa i-glucose yegazi ngokukhawuleza.Ukongeza, i-DNJ inefuthe le-insulin sensitization ukuphucula ukumelana ne-insulin.
2. Ukunciphisa iswekile yegazi emva kokutya.
I-α- I-Glucosidase isasazwa kakhulu emathunjini amancinci omntu kwaye idlala indima ebalulekileyo ekubola kwe-carbohydrates.Bajongene nokubola kwe-oligosaccharides ezifana ne-oligosaccharides ekudleni kwi-monosaccharides, njenge-glucose.Le glucose ingena emzimbeni ngodonga lwamathumbu, ibangela ukunyuka okubukhali koxinzelelo lweglucose yegazi.I-DNJ yendalo kwaye inamandla i-α-Glucosidase inhibitors ebopha ngokukhuphisanayo emathunjini amancinci α- Ubudlelwane be-glucosidase buphezulu kune-oligosaccharides ezifana ne-sucrose kunye ne-maltose i-α-Glucosidase inobudlelwane obuqinileyo kwaye iyanciphisa i-oligosaccharides kunye ne-alpha-glucosidability , ukwenzela ukuvimbela ukubola kwe-fructose kwi-glucose, kwaye isixa esikhulu seswekile asiyi kuxutywa kwaye sithunyelwe emathunjini amakhulu.Ngenxa yempembelelo ye-DNJ, i-glucose encinci ingena egazini, ngoko ke i-glucose yegazi ifanelekile ukugcinwa kwinqanaba eliphilileyo.
3. Ukuzila ukutya kweglucose yegazi.
I-DNJ inomsebenzi we-inhibitory we-glycogen phosphorylase, enokunciphisa ukuthotywa kwesibindi se-glycogen kwi-glucose, ukuze kuzinzise ukuzila i-glucose yegazi.I-glucose "eyongezelelweyo" emzimbeni womntu igcinwe esibindi ngendlela ye-glycogen.I-Glycogen inokuqhekeka ibe yi-glucose phantsi kwesenzo se-glycogen phosphorylase kwaye ikhutshwe egazini ukuze ihlangabezane neemfuno zemisipha kunye neminye imisebenzi yamalungu.I-Glycogen yenye yezona zinto ziphambili zamandla okusebenza ngokwasemzimbeni.Ngokutshintshana phakathi kwe-glycogen kunye ne-glucose, i-glucose yegazi yabantu abaqhelekileyo ikwi-balance balance.Kwizigulane ezinesifo seswekile, ngenxa yokungasebenzi kakuhle kwe-glucose metabolism, i-glycogen eninzi kakhulu iya kuhla ibe yi-glucose, okukhokelela ekunyukeni okungaqhelekanga kwi-glucose yegazi ngokukhawuleza.I-DNJ inokuthintela umsebenzi we-glycogen phosphorylase kwaye ithintele ukunyuka kwe-glucose yegazi okubangelwa ukubola okugqithisileyo kwe-glycogen kwi-glucose, ukuze kuzinzise ukuzila i-glucose yegazi.
4. Ukuphucula ukuxhathisa kwe-insulin.
I-DNJ inokuphucula iimpawu zokunganyangeki kwe-insulin ngokulungisa i-lipid metabolism, ukunciphisa ukuveliswa kwe-glucose kunye ne-insulin sensitization.Ukunganyangeki kwe-insulin kubhekiselele kwizizathu ezahlukahlukeneyo (ingakumbi ezibandakanya imiba yemfuza kunye nokutyeba), ezinciphisa ukusebenza kwe-insulin ekhuthaza ukufunjwa nokusetyenziswa kwe-glucose, kwaye umzimba uhlawulela i-insulin eninzi kakhulu.Ukumelana ne-insulin kuvelisa i-hyperinsulinemia ukugcina uzinzo lwe-glucose yegazi emzimbeni.Ukuba umzimba womntu ukwimeko yokuxhathisa i-insulin ixesha elide, kuya kwandisa kakhulu umthwalo we-pancreas.Inokubangela ukuba i-pancreas ikhuphe ukusilela komsebenzi we-insulin kwaye emva koko ikhule ibe sisifo seswekile.I-DNJ inokuphucula iimpawu zokunganyangeki kwe-insulin ngokugcina i-glucose yegazi enempilo, ukulungisa i-lipid metabolism kunye nokwandisa ukuvakalelwa kwe-insulin.
2, imimandla yokusetyenziswa kwegqabi le-mulberry DNJ
Igqabi le-mulberry igqabi le-mulberry i-DNJ idweliswe njenge-axiliary hypoglycemic effect kwaye isetyenziswa ngokubanzi ekutyeni okunempilo.

IiParameters zeMveliso

IPROFAYILE YEKHAMPANI
Igama lemveliso	Igqabi le-Mulberry DNJ
CAS	19130-96-2
Ifomula yeMichiza	C6H13NO4
Birandi	Hkwaye
Mumenzi	Yunnan Hande Bio-Tech Co., Ltd.
Cukuphuma	Kunming,Chayi
Isekiwe	1993
BINGCACISO YEASIC
Izithethantonye	(2r,3r,4r,5s) -2-hydroxymethyl-3,4,5-trihydroxypiperidine;5-piperidinetriol,2-(hydroxymethyl)-,(2r-(2alpha,3beta,4alpha,5beta))-4;bay-h5595;moranolin;moranoline; (+)-1-DEOXYNOJIRIMYCIN;1-DEOXYNOJIRIMYCIN;(2R,3R,4R,5S)-2-(HYDROXYMETHYL)-3,4,5-PIPERIDINETRIOL
Ulwakhiwo
Ubunzima	N / A
HS Ikhowudi	N / A
UmgangathoSukucaciswa	Inkcazo yeNkampani
CIzaziso	N / A
Isivavanyi	Customized ngokweemfuno zabathengi
Imbonakalo	Umgubo omhlophe
Indlela yokutsalwa	Ikhutshwe kumagqabi e-mulberry kunye ne-root bark
Ubunakho boNyaka	Customized ngokweemfuno zabathengi
Iphakheji	Customized ngokweemfuno zabathengi
Indlela yoVavanyo	HPLC
Ulungiselelo	Ezininziuthuthos
PaymentTerms	T/T, D/P, D/A
Oapho	Yamkela uphicotho lwabathengi ngalo lonke ixesha;Ukunceda abathengi ngobhaliso lolawulo.

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