Izinto ezilungileyo ze-Albumin-bound paclitaxel

I-Paclitaxel yenye yamachiza amachiza e-chemotherapy esizukulwana sesithathu, kodwa ukunyibilika kwayo kwamanzi akubi kakhulu kwaye kufuneka kunyibilike kunye ne-organic solvents.I-Albumin-bound paclitaxel isebenzisa i-nanotechnology ukunyusa ukuhanjiswa kweziyobisi kunye ne-bioavailability ye-paclitaxel ngoncedo lwe-albumin yendalo. inqanda kuphela i-hypersensitivity/ityhefu yokusabela okubangelwa zizinyibilikisi zezinto eziphilayo, kodwa kwakhona ayifuni unyango lwangaphambili lwehomoni; Inokwenza ukuba i-albumin ikhuphe i-paclitaxel ngaphandle kokujikeleza kwegazi ngokukhawuleza, idlule kwiiseli ze-endothelial ngokusebenzisa i-receptor mediated endocytosis, kwaye ityebise ngakumbi kwizicubu zethumba. ngokusebenzisa i-permeability ephezulu kunye nesiphumo sokugcina (i-EPR effect) yamathumba, eqhubeka nokubonisa inzuzo ye-pharmacokinetic.

Ngexesha lonyango lwe-immunotherapy, ukusebenza kwechiza elinye akwanelanga, kwaye izinga lokuxolelwa kwenjongo (ORR) yechiza elinye alidluli i-20%; indlela yechemotherapy edityanisiweyo yindawo eshushu yophononongo lwangoku.

Ngokwale mbono, i-Albumin-bound paclitaxel ineenzuzo zayo, i-ORR yayo iphezulu, inokubulala iiseli zethumba ngempumelelo ngakumbi, kwaye ikhuthaze ukuvezwa kwe-antigen ye-tumor; Akukho nyango lwangaphambili lwehomoni luyafuneka ukunqanda ukugonywa; Ukutyeba okuphezulu kwethumba kunciphisa umonakalo izicubu eziqhelekileyo.

Qaphela:Ukusebenza okunokwenzeka kunye nezicelo eziveliswe kweli nqaku zonke zivela kuncwadi olupapashiweyo.

I-Yunnan Hande Biotechnology Co., Ltd ibigxile ekuvelisenipaclitaxel APIngaphezulu kweminyaka engama-20, kwaye ngomnye wabavelisi behlabathi abazimeleyo be-paclitaxel API, ichiza eliphuma kwisityalo elichasene nomhlaza, elivunywe yi-US FDA, i-European EDQM, i-Australian TGA, iCFDA yamaTshayina, iIndiya, iJapan kunye nezinye iiarhente ezilawula ilizwe. .I-Hande ayinikezeli kuphela umgangatho ophezulupaclitaxel imathiriyeli ekrwada,kodwa kunye neenkonzo zophuculo lobugcisa ezinxulumene ne-paclitaxel formulation.Ngolwazi oluthe kratya, nceda uzive ukhululekile ukuqhagamshelana nathi ku-18187887160.