Kolu xinizelelo luphezulu, isingqisho esiphakamileyo kunye nemeko-bume ekhawulezayo yokuhlala, abanye abantu bahlala belibazisa ixesha labo lokulala ebusuku, nto leyo eyenza kube nzima ukulala, okukhokelela kukuphazamiseka kokulala. Kufuneka senze ntoni? Ukuba kukho ingxaki, kuya kubakho ibe yindlela yokusombulula ingxaki.
Ngeli xesha abantu abaninzi bevamelatonin,bacinga ukuba i-melatonin yimveliso yobuhle.Enyanisweni, i-melatonin yi-hormone yangaphakathi eyenza ubuthongo bendalo.Iyoyisa imiqobo yokulala kwaye iphucule umgangatho wokulala ngokulawula ubuthongo bendalo babantu. nceda ukulala.
Ngokweenkcukacha-manani zoMbutho wezeMpilo weHlabathi, izinga lokuphazamiseka kokulala kwihlabathi lingama-27%, nto leyo eye yaba sisifo sengqondo esixhaphakileyo ehlabathini. I-insomnia.Ingxelo ekhutshwe ngumbutho waseTshayina wophando ngobuthongo ibonisa ukuba bangaphezu kwezigidi ezingama-300 abantu baseTshayina abanengxaki yokungalali, ngelixa izinga lokuphuthelwa kwabantu abadala lifikelela kuma-38.2%.
Ngaba ngokwenene iMelatonin inokunceda ebuthongweni?
###Masijonge imelatonin kunye nendima yayo.
I-Melatonin(MT) yenye yeehomoni eziveliswa yi-pineal gland.I-Melatonin yeye-indole heterocyclic compounds.Igama layo lekhemikhali yi-N-acetyl-5 methoxytryptamine, eyaziwa ngokuba yi-pinealoxin.Emva kwe-melatonin synthesis, igcinwa kwi-pineal gland. Imincili yovelwano yenza ukuba iiseli ze-pineal gland zikhuphe i-melatonin. Ukukhutshwa kwe-melatonin kunesingqisho esicacileyo se-circadian, esithintelwa emini kwaye sisebenze ebusuku.
I-Melatonin inokuthintela i-hypothalamic pituitary gonadal axis, inciphise imixholo ye-gonadotropin ekhupha ihomoni, i-gonadotropin, i-hormone ye-luteinizing kunye ne-follicular estrogen, kwaye isebenze ngokuthe ngqo kwi-gonads ukunciphisa imixholo ye-androgen, i-estrogen kunye ne-progesterone. Umphathi oyintloko we-endocrine.Ilawula imisebenzi yamadlala ahlukeneyo e-endocrine emzimbeni, ngaloo ndlela ilawula ngokungangqalanga umsebenzi womzimba wethu uphela.
Umsebenzi kunye noLawulo lweMelatonin
1)Lungisa isingqisho se-circadian
Ukongezwa kwe-melatonin evela ngaphandle komzimba kunokugcina inqanaba le-melatonin emzimbeni kwimeko emncinci, ukulungelelanisa nokubuyisela isigqi se-circadian, kungekuphela nje ukulala nzulu kunye nokuphucula umgangatho wokulala, kodwa nokuphucula imeko yokusebenza umzimba wonke, uphucula umgangatho wobomi kunye nokulibazisa inkqubo yokuguga.Ngenxa yokukhula kweminyaka, i-pineal gland iyancipha de i-calcification, ibangele ukuba buthathaka okanye ukunyamalala kwesingqisho sewotshi yebhayoloji.Ingakumbi emva kweminyaka engama-35 ubudala, I-melatonin eveliswa ngumzimba iyancipha kakhulu, kunye nokuncipha kwe-avareji ye-10 ~ 15% rhoqo kwiminyaka eyi-10, okukhokelela kukuphazamiseka kokulala kunye nothotho lweengxaki zokusebenza. ukwaluphala.
2)Ukulibaziseka ukuguga
I-pineal gland yabantu abadala iyancipha ngokuthe ngcembe, kwaye i-secretion ye-MT iyancipha ngokufanelekileyo.Ubungakanani beMel obufunwa ngamalungu ahlukeneyo emzimbeni awanelanga, okubangela ukuguga kunye nezifo.Izazinzulu ziyibiza i-pineal gland iwashi yokuguga komzimba.Xa sincedisa MT ngaphandle, sinokuyibuyisela umva iwotshi yokuguga.
3) Thintela izilonda
Ngenxa yokuba i-MT inokungena lula kwiiseli, ingasetyenziselwa ukukhusela i-DNA yenyukliya.Ukuba i-DNA yonakele, inokukhokelela kumhlaza.Ukuba kukho iMel eyaneleyo egazini, akulula ukufumana umhlaza.
I-4) Impembelelo yokulawula kwinkqubo ye-nervous central
Inani elikhulu lezifundo zeklinikhi kunye novavanyo lubonisa ukuba i-melatonin, njengehomoni ye-neuroendocrine engapheliyo, inolawulo oluthe ngqo kunye olungathanga ngqo lwe-physiological system kwinkqubo ye-nervous central, iziphumo zonyango kwiingxaki zokulala, ukudakumba kunye nezifo zengqondo, kunye neziphumo zokukhusela kwiiseli ze-nerve. I-melatonin inefuthe lokuthomalalisa, inokunyanga ukudakumba kunye nengqondo, inokukhusela imithambo-luvo, inokuphelisa iintlungu, ilawule iihomoni ezikhutshwa yi-hypothalamus njalo njalo.
5) Ukulawulwa kwamajoni omzimba
Kwiminyaka elishumi yakutshanje, impembelelo elawulayo ye-melatonin kumajoni omzimba iye yatsala ingqalelo ebanzi. Uphononongo lwasekhaya nakwamanye amazwe lubonise ukuba i-melatonin ayichaphazeli nje kuphela ukukhula nophuhliso lwamalungu omzimba, kodwa ikwalawula ukunganyangeki kwe-humoral, ukunganyangeki kweeseli kunye neecytokines. Ngokomzekelo, i-melatonin inokulawula ukugonywa kweeseli kunye ne-humoral, kunye nomsebenzi weentlobo ezahlukeneyo ze-cytokines.
I-6) Impembelelo yokulawula kwi-cardiovascular system
Umsebenzi we-vascular system unesigqi esicacileyo se-circadian kunye nesigqi sonyaka, kubandakanywa uxinzelelo lwegazi, izinga lentliziyo, ukuphuma kwentliziyo, i-renin angiotensin aldosterone, njl njl. Ukongeza, iziphumo zovavanyo ezifanelekileyo ziqinisekisile ukuba ukunyuka kwe-MT secretion ebusuku kwakuhambelana kakubi nokuncipha komsebenzi we-cardiovascular; I-Pineal melatonin inokuthintela i-arrhythmia ebangelwa yi-ischemia-reperfusion nzakala, ichaphazela ukulawula uxinzelelo lwegazi, ilawula ukuhamba kwegazi kwi-cerebral, kwaye lawula i-reactivity ye-peripheral arteries kwi-norepinephrine.
7) Ukongeza, imelatonin ikwalawula inkqubo yokuphefumla yomntu, inkqubo yokwetyisa kunye nenkqubo yomchamo.
Ingcebiso yeMelatonin
melatoninayisiyo iziyobisi.Inokudlala kuphela indima encedisayo ekuphuthelweni kwaye ayinayo impembelelo yonyango.Ngeengxaki ezifana nomgangatho ophantsi wokulala kunye nokuvuka phakathi, akuyi kuba nomphumo obalulekileyo wokuphucula.Kwezi meko, kufuneka ufune unyango lwezonyango. ngexesha kwaye ufumane unyango oluchanekileyo lwechiza.
Ngaba uyafuna ukwazi ngakumbi malunga ne-melatonin? I-Hande izimisele ukubonelela abathengi ngeemveliso ezingcono nezinempilo zokutsalwa.Sibonelela ngeemveliso ze-melatonin ezikumgangatho ophezulu kunye nezikumgangatho ophezulu ukukunceda ngokufanelekileyo uphucule ubuthongo bakho kwaye uphile ngokufanelekileyo yonke imihla!
Ixesha lokuposa: May-11-2022