Iimpawu ze-albumin-bound paclitaxel,Ichiza lokulwa nomhlaza

I-Paclitaxel yimveliso yendalo ethatyathwe kwi-Taxus, esebenza kwi-tubulin ukunqanda i-mitosis yeeseli zethumba. Ukuza kuthi ga ngoku, i-paclitaxel lelona chiza libalaseleyo lokulwa nomhlaza eliye lafunyanwa. ukusebenza kakuhle kweklinikhi kunyango lomhlaza wamabele, umhlaza wesibeleko, umhlaza wemiphunga ongeyonxalenye encinci, umhlaza we-gastroesophageal kunye namanye amathumba.

Ngenxa yokuba i-paclitaxel yendabuko i-lipophilic kakhulu, kwaye isithako esisebenzayo sinzima ukunyibilika emanzini, i-ethanol anhydrous, i-polyoxyethylene ioli ye-castor, njl. kwaye kwiimeko ezinzima, ukothuka kwe-anaphylactic kunokwenzeka, ukubeka ubomi emngciphekweni.Izehlo zokuxhatshazwa ziphezulu ukuya kuma-20% -40%.Ukuthintela okusebenzayo, unyango lwangaphambili lwe-corticosteroids kunye ne-antihistamines kufuneka lwenziwe phambi kokulawulwa.I-Paclitaxel kufuneka ihlanjululwe Inani elikhulu phambi kokutofa nge-intravenous, kwaye ixesha lokutofa kufuneka ligcinwe ubuncinane kwiiyure ezi-3.

Ukuze soyise esi siphene, i-albumin-bound bound paclitaxel iye yabakho.I-albumin-bound-bound paclitaxel idibanisa i-hydrophobic paclitaxel kunye ne-albumin ukuze yenze i-nanoparticles enobungakanani besuntswana elimalunga ne-130 nm ngokusebenzisa i-nanotechnology eyodwa.Isebenzisa indlela eyodwa yokuthutha yendalo yendalo I-albumin ukwenza i-paclitaxel isasazeke ngakumbi kwizicubu ze-tumor kwaye ifikelele kugxininiso oluphezulu kwiiseli zethumba; Inqanda ukusetyenziswa kwe-ethanol ene-anhydrous, i-polyoxyethylene castor oil kunye nezinye izinto ezinyibilikayo, inciphisa kakhulu ukuvela kwe-allergies, kwaye ayifuni kunyango lwangaphambi kokusetyenziswa. ,kwaye akukho mfuneko yokuba isebenzise isixhobo esikhethekileyo sokugalela.Ukufakwa kungagqitywa kwisiqingatha seyure.Ngenene kuphumeza isiphumo sonyango esiphakamileyo kunye netyhefu ephantsi.

Qaphela:Ukusebenza okunokwenzeka kunye nezicelo eziveliswe kweli nqaku zonke zivela kuncwadi olupapashiweyo.

I-Yunnan Hande Biotechnology Co., Ltd ibigxile ekuvelisenipaclitaxel APIngaphezulu kweminyaka engama-20, kwaye ngomnye wabavelisi behlabathi abazimeleyo be-paclitaxel API, ichiza eliphuma kwisityalo elichasene nomhlaza, elivunywe yi-US FDA, i-European EDQM, i-Australian TGA, iCFDA yamaTshayina, iIndiya, iJapan kunye nezinye iiarhente ezilawula ilizwe. .I-Hande ayinikezeli kuphela umgangatho ophezulupaclitaxel imathiriyeli ekrwada,kodwa kunye neenkonzo zophuculo lobugcisa ezinxulumene ne-paclitaxel formulation.Ngolwazi oluthe kratya, nceda uzive ukhululekile ukuqhagamshelana nathi ku-18187887160.