Ubume bekhemikhali kunye nesenzo se-pharmacological ye-paclitaxel

I-Paclitaxel (i-Paclitaxel) iyiyeza le-antiticancer yendalo ekhutshwe kwisityalo se-yew, esinokwakheka kweekhemikhali ezizodwa kunye nemiphumo ye-pharmacological.Ukususela ekufumaneni i-paclitaxel kwi-1971, isicelo sayo seklinikhi siye safumana iziphumo eziphawulekayo.Kweli phepha, ubume beekhemikhali kunye nesenzo se-pharmacological ofpaclitaxelkuya kuxutyushwa.

Ubume beMichiza ye-paclitaxel

Ukwakhiwa kweekhemikhali ze-paclitaxel yinkimbinkimbi, equkethe izakhiwo ezininzi zendandatho, kubandakanywa isakhiwo esisisiseko se-diterpenoid, eyona nxalenye ephambili yempembelelo ye-anti-cancer ye-paclitaxel.Iimolekyuli zePaclitaxel nazo ziqulethe inani le-hydroxyl kunye namaqela e-ketone, kwaye indawo kunye nenani lala maqela limisela umsebenzi walo okhethekileyo we-pharmacological.

Iziphumo ze-pharmacological ze-paclitaxel

1. Ukuqiniswa kwe-Microtubule: I-Paclitaxel inokukhuthaza i-polymerization ye-microtubules kunye nokuzinzisa i-polymerized microtubules, eyona ndlela iphambili yempembelelo yayo ye-anticancer.I-Microtubules idlala indima ebalulekileyo ekuhlukaneni kweeseli, kwaye i-paclitaxel inqanda ukukhula kwe-tumor ngokuzinzisa i-microtubules kunye nokuthintela ukuhlukana kweeseli.

I-2, yenza ukuba kubanjwe umjikelo weseli: i-paclitaxel inokubangela ukubanjwa komjikelo weseli, ukuze iiseli zingakwazi ukuqhubeka nokwahlula kunye nokwanda.Le yenye indlela ebalulekileyo yempembelelo yayo yokulwa nomhlaza.

I-3, yenza i-apoptosis: i-paclitaxel inokukhuthaza ukubonakaliswa kwabaninzi abalamli be-pro-apoptosis, ukukhawulezisa inkqubo ye-apoptosis yeeseli zomhlaza.

I-4, ukulawulwa kwe-anti-apoptotic mediators: i-paclitaxel inokulawula umsebenzi wabalamli be-anti-apoptotic ukulungelelanisa inkqubo ye-apoptosis kunye nokusabalalisa.

Ukuqukumbela

I-Paclitaxel luhlobo lwechiza lendalo le-anticancer elinesakhiwo esisodwa sekhemikhali kunye nesenzo se-pharmacological.Inokuthintela ngokufanelekileyo ukukhula kwe-tumor ngokukhuthaza i-polymerization ye-microtubule, ukuzinzisa ii-microtubules ze-polymerized, ukukhuthaza ukubanjwa komjikelo weseli kunye nokunyanzelwa kwe-apoptosis yeseli.Nangona kunjalo, ubutyhefu kunye neziphumo ebezingalindelekanga ze-paclitaxel zikwayinkxalabo kwizicelo zeklinikhi.Uphando olongezelelweyo kunye nokuqonda imiphumo ye-pharmacological ye-paclitaxel iya kunceda ukwandisa ukusetyenziswa kwayo kweklinikhi, ukuphucula ukusebenza konyango, kunye nokunciphisa imiphumo emibi.

Ikamva elizayo

Nangona ukusetyenziswa kweklinikhi ye-paclitaxel kuzuze iziphumo eziphawulekayo, ingxaki yezibonelelo zayo ezinqamlekileyo kunye nokubonelelwa okuqinileyo kusekho.Ngoko ke, izazinzulu kwiinkalo zebhayoloji yokwenziwa kunye nekhemistri yamayeza zisebenza ukufumana ezinye iindlela kwi-paclitaxel ukusombulula iingxaki zayo zokubonelela kunye nokunciphisa iindleko zokuvelisa.Ukongeza, uphando kwiziphumo ze-pharmacological zepaclitaxelkuya kunceda ukufumanisa iindlela zonyango ezisebenzayo ngakumbi ukujongana neentlobo ezahlukeneyo zomhlaza.

Kwizifundo zangaphambi kweklinikhi kunye nolingo lwezonyango, indibaniselwano ye-paclitaxel kunye namanye amachiza e-anticancer ibonise ithemba elithembisayo.Ngokudibanisa i-paclitaxel kunye namanye amachiza, ukusebenza kwonyango kunokuphuculwa kunye nokuvela kokumelana nokunciphisa.Kwixesha elizayo, ngokusasazwa kwamayeza achanekileyo kunye neengcamango zonyango lomntu, uphando kunye nokuqonda imiphumo ye-pharmacological ye-paclitaxel iya kuba nzulu ngakumbi, kwaye iinkqubo zonyango ezichanekileyo nezisebenzayo ziya kubonelelwa kwizigulane ezinomhlaza.

Ngokubanzi, i-paclitaxel iyeza lendalo le-anticancer elinokwakheka kweekhemikhali ezizodwa kunye nemiphumo ye-pharmacological.Ngenkqubela phambili eqhubekayo yenzululwazi nobuchwepheshe kunye nophando olunzulu, sijonge phambilipaclitaxelukudlala indima enkulu kunyango lwemihlaza eyahlukeneyo kwixesha elizayo, ukuzisa iziphumo ezingcono zonyango kunye nomgangatho wobomi kwizigulana.

Qaphela: Iingenelo ezinokusetyenziswa kweli nqaku zifumaneka kuncwadi olupapashiweyo.