I-paclitaxel ilwa njani nomhlaza?

I-Paclitaxel yi-diterpenoid ekhutshwe kwi-Taxus genus Taxus, kwaye izazinzulu ziye zafumanisa ukuba inomsebenzi onamandla we-antitumor ekuhloleni ukuhlolwa.Ngoku,paclitaxelisetyenziswa kakhulu kunyango lomhlaza wamabele, umhlaza wesibeleko, umhlaza wemiphunga weseli engeyiyo encinci, umhlaza wepancreatic, umhlaza wommizo, umhlaza wesisu, ithumba lentloko nentamo, izicubu ezithambileyo zesarcoma kunye namanye amathumba ayingozi, kwaye yenye yezona zinto zixhaphakileyo. wasebenzisa amachiza e-chemotherapy kwimisebenzi yeklinikhi.Ke i-paclitaxel ilwa njani nomhlaza?Makhe sijonge ngezantsi.

I-paclitaxel ilwa njani nomhlaza?Kuyaziwa ukuba ngexesha lokuhlukana kweeseli eziqhelekileyo, iseli yahlulwe yangamacandelo amabini.Emva kokuba ichromosome iphindaphindwe, intambo yokuphotha iyayitsala ukusuka kwindawo yayo yokuqala ukuya kumacala omabini, kwaye i-spindle idinga i-depolymerization ye-microtubules njengoko i-cytoskeleton yenzekile, i-Chromosomes inokugqiba kuphela i-mitosis ngokufudukela kwiipali phantsi kwentambo yokujikeleza kwaye i-spindle filament, ngoko ke ii-microtubules zibaluleke kakhulu kwi-cell division.

Ngo-1979, usokhemesti uHorwitz wafumanisa ukubapaclitaxelinokubophelela kwi-tubulin kwaye ikhuthaze i-polymerization ye-tubulin ukwenza i-microtubules, ngaloo ndlela inqanda ukuchithwa kwe-physiological disaggregation ye-microtubules, okwenza ukuba ingakwazi ukwenza i-spindles kunye ne-spindle filaments, ukwenza iiseli Ukungakwazi ukwahlula ngokuqhelekileyo kuthintela ukuveliswa ngokukhawuleza kweeseli zomhlaza kwaye kubangele i-apoptosis. yeeseli zomhlaza.Ke ngoko, phakathi kwamachiza e-anticancer, i-paclitaxel ithathwa njenge-microtubule inhibitor kwi-mitosis.

Qaphela: Ukusebenza okunokwenzeka kunye nokusetyenziswa okuchazwe kweli nqaku kuthathwe kuncwadi olupapashiweyo.

Ufundo olwandisiweyo:I-Yunnan Hande Biotechnology Co., Ltd. sele igxile kwimveliso ye-paclitaxel iminyaka eyi-28.Ngumvelisi wokuqala ozimeleyo wehlabathi we-anticancer drug paclitaxel evunywe yi-US FDA, i-European EDQM, i-Australian TGA, i-China CFDA, i-Indiya, i-Japan kunye nezinye ii-arhente ezilawulayo zelizwe.ishishini.Ukuba ufuna ukuthengaPaclitaxel API,nceda uqhagamshelane nathi kwi-intanethi.