I-paclitaxel yendalo: ichiza le-anticancer elisebenza kakhulu kwaye liphantsi

I-Paclitaxel, ichiza le-anticancer yendalo kunye nefomula ye-C47H51NO14, isetyenziswe ngokubanzi kunyango lomhlaza webele, umhlaza we-ovari kunye nomhlaza wentloko, intamo kunye nemiphunga.Njenge-alkaloid ye-diterpenoid enomsebenzi we-anticancer,paclitaxeliye yathandwa kakhulu ziingcali zezityalo, iikhemisti, izazi zenzululwazi zezamayeza kunye neengcali zebhayoloji ngenxa yenoveli yayo kunye nokwakheka kweekhemikhali ezintsonkothileyo, umsebenzi obanzi nobalulekileyo webhayoloji, indlela entsha neyodwa yokwenza, kunye nemithombo yendalo enqongopheleyo, iyenza ibe yinkwenkwezi kunye nojoliso kuphando lwe-anticancer kwisiqingatha sesibini senkulungwane yama-20.

Inkqubo yesenzo se-paclitaxel

I-Paclitaxel inqanda ukwanda kweeseli zomhlaza ikakhulu ngokubangela ukubanjwa komjikelo weeseli kunye nokubangela intlekele ye-mitotic.Inoveli yayo kunye nolwakhiwo lwekhemikhali oluntsonkothileyo lunika indlela ekhethekileyo yebhayoloji yokusebenza.Paclitaxelinokuthintela ukwanda kweeseli ngokuthintela i-polymerization ye-tubulin kunye nokutshabalalisa inethiwekhi ye-cell microtubule.Ukongeza, i-paclitaxel inokukhuthaza ukubonakaliswa kwabalamli be-pro-apoptotic kwaye ilawule umsebenzi wabalamli be-anti-apoptotic, ngaloo ndlela ikhuthaza i-apoptosis yeeseli zomhlaza.

Umsebenzi wokulwa nomhlaza we-paclitaxel

I-Paclitaxel iye yatsala ingqalelo enkulu ngenxa yokusebenza kwayo okuphezulu kunye netyhefu ephantsi yomsebenzi we-anticancer.Kwinkqubo yeklinikhi, i-paclitaxel ibonakaliswe ukuba ineziphumo ezibalulekileyo zonyango kwiintlobo ezahlukeneyo zomhlaza, kubandakanya umhlaza webele, umhlaza we-ovarian, ezinye iintloko kunye nomhlaza wentamo, kunye nomhlaza wemiphunga.Ngendlela yayo ekhethekileyo yebhayoloji, i-paclitaxel inokuthintela ngokusebenzayo ukwanda kweeseli zomhlaza kwaye yenze i-apoptosis yeeseli zomhlaza.Ukongeza, umsebenzi wokulwa nomhlaza we-paclitaxel ukwanxulumene namandla ayo okulawula ukuphendula komzimba kwiiseli zethumba.

Ukunqongophala kovimba we-paclitaxel

Nangona i-paclitaxel inomsebenzi obalulekileyo we-anticancer, ukunqongophala kwezixhobo kuthintele ukusetyenziswa kwayo ngokubanzi kweklinikhi.I-Paclitaxel ikhutshwe kakhulu kwimithi ye-Pacific yew, kwaye ngenxa yobuncwane bendalo obuncinci, ukuveliswa kwe-paclitaxel kukude ukuhlangabezana neemfuno zekliniki.Ngoko ke, ukukhangela imithombo emitsha ye-paclitaxel, njengokuveliswa kwe-paclitaxel nge-biosynthesis okanye i-chemical synthesis, kugxininiso lophando lwangoku.

isiphelo

Njengechiza lendalo lokulwa nomhlaza,paclitaxelineempawu zobuchule obuphezulu, ubutyhefu obuphantsi kunye nobubanzi obubanzi, kwaye indlela yayo ekhethekileyo yebhayoloji yokusebenza kunye nomsebenzi obalulekileyo wokulwa nomhlaza kuyenza ibe lichiza elibalulekileyo lonyango lomhlaza kwiklinikhi.Nangona kunjalo, ngenxa yokunqongophala kwezibonelelo zayo, ukusetyenziswa kwayo ngokubanzi kwiklinikhi kulinganiselwe.Ngoko ke, uphando lwexesha elizayo kufuneka lugxininise ekufumaneni imithombo emitsha ye-paclitaxel ukuhlangabezana neemfuno zeklinikhi kunye nokubonelela ngeendlela ezininzi zonyango kwizigulane zomhlaza.

Qaphela: Iingenelo ezinokusetyenziswa kweli nqaku zifumaneka kuncwadi olupapashiweyo.