Natural Paclitaxel VS Semi-synthetic Paclitaxel (I)

Isixhobo Amayeza

I-Paclitaxel, njengechiza le-anticancer, isetyenziswa ngokubanzi kwii-Injection ezahlukeneyo kunye nezixhobo.

Ikakhulu yenziwe ngokutsalwa kwendalo kunye nokudibanisa.

Njengomthombo wesityalo se-paclitaxel ekhutshwe ngokwendalo, i-Taxus Chinensis, inqabile kwaye inomjikelezo omde wokukhula, uthotho lweendlela zokudibanisa ziye zathathwa ngokucothayo kwi-paclitaxel ngophando kunye novavanyo kwihlabathi liphela, kubandakanywa ne-synthesis epheleleyo, i-semi-synthesis, kunye i-endophytic synthesis.

Ngenxa yendlela ende yokudityaniswa kweekhemikhali, amanyathelo amaninzi okudibanisa, kwaye kunzima ukulawula iimeko zokusabela, i-paclitaxel eyenziwe ngokupheleleyo kufuneka isebenzise ii-reagents zeekhemikhali ezibiza kakhulu, kwaye isivuno siphantsi, esingafanelekanga kwimveliso yobuninzi kunye nemveliso yemizi-mveliso. jikelele.

Ke ngoko, isixa esikhulu se-paclitaxel kwimarike senziwa ngokubanzi ngokutsalwa kwendalo kwetaksi ezilinywayo kunye neendlela ze-semi-synthetic.

I-Paclitaxel yendalo vs i-Semi-synthetic Paclitaxel

Icandelo 1: Inkqubo yeMveliso

I-paclitaxel yendalo:

-Imathiriyeli ekrwada:IYew etyalwe ngokwenziwa

-Inkqubo yokutsalwa:izinto ezikrwada+ikholamu yechromatography+recrystallization=imveliso egqityiweyo

-Inkqubo yokutsalwa: ukusabela ngokwasemzimbeni, akukho nkqubo yokwenziwa kweekhemikhali

I-Semi-synthetic Paclitaxel:

-Imathiriyeli ekrwada:IYew etyalwe ngokwenziwa

-Inkqubo yokukhupha:izinto ezikrwada+ikhemikhali ireagent reaction+ikristale egxininisiweyo+indlela ezahlukeneyo zokusabela kweekhemikhali+recrystallization=imveliso egqityiweyo

-Inkqubo yokukhutshwa: ukusabela kweekhemikhali

Ngokobuchwephesha, i-paclitaxel yendalo inamanyathelo alula okutsalwa xa kuthelekiswa ne-semi-synthetic paclitaxel kunye neenzuzo ezingaphezulu kwe-semi-synthetic paclitaxel ngokozinzo nokhuseleko, ngelixa i-semi-synthetic paclitaxel inciphisa iindleko zophuhliso lwemveliso ngokwexabiso kunye nezinto ezikrwada. ,kwaye ikwaphucula ezinye iingxaki ezibangelwa kukunqaba kwemathiriyeli ekrwada emarikeni.

Xa kuthelekiswa neendlela ezimbini zokuvelisa i-paclitaxel, i-paclitaxel yendalo inozinzo olungcono kunye nokhuseleko kwizixhobo zonyango, nto leyo ebangela ukuba iinkampani ezininzi zezixhobo zonyango kwimarike zisebenzisa i-paclitaxel yendalo njengento eluhlaza.

IYunnan Hande Biotechnology Co.,Ltd.isebenze ekutsalweni nasekuphuhliseni iirhafu iminyaka engama-30,kwaye iimveliso zayo ezingundoqo yipaclitaxel yendalo,10-DAB semi-synthetic paclitaxel,10-deacetylbaccatin III,docetaxel,cabazitaxel, njl. ulwazi oluthe kratya malunga ne-paclitaxel APIs, nceda uqhagamshelane nathi !!!(Whatsapp/Wechat:+86 18187887160)