Natural Paclitaxel VS Semi-synthetic Paclitaxel(II)

Isicatshulwa seYew taxus chinensis sitsalwa kwizityalo ezinqabileyo zendalo, ezibekwe, isiqu, ulusu, ingcambu iqulathe ezona zithako zezi:yew alkali diterpenoid ikhompawundi,yew ning A kunye yew,yew ning H,yew,yew ning K,l,yew alkali, I-jinsong yellow ketone, ithambeka elishiya i-A, le ishiya i-ketone ketone, i-jinsong ephindwe kabini yeketone emthubi, i-naphtha, i-yew, i-polysaccharide, i-tannins, i-tanned ebomvu, njl. anti-leukemia kunye nemiphumo ye-tumor.

I-Paclitaxel, esiza kuthetha ngayo, lelona chiza libalaseleyo lokuchasa umhlaza eliye lafunyanwa ukuza kuthi ga ngoku.Isetyenziswe ngokubanzi kunyango lomhlaza webele, umhlaza wesibeleko, umhlaza wentloko kunye nentamo, umhlaza wamaphaphu kunye nabaninzi. ezinye zomhlaza ngokwezonyango.

I-Paclitaxel yendalo vs i-Semi-synthetic Paclitaxel

Ukungcola:

I-paclitaxel yendaloikhutshwe kwiingcambu, iziqu kunye namagqabi e-Taxus chinensis.Emva kwekholamu yechromatography kunye ne-recrystallization, yonke le nkqubo isicatshulwa somzimba kunye nokuhlanjululwa ngaphandle kweekhemikhali. eziswa yikhemikhali synthesis.Ngoko ke, ukulungiswa kokungcola kwe-paclitaxel yendalo kufundwa ngokupheleleyo kwaye kulawulwa ngakumbi ngoku.

I-semi-synthetic paclitaxelinokwakheka kweekhemikhali ezininzi kunezendalo kwinkqubo yayo, kwaye imithombo yokungcola kwayo ingaphezulu kwezendalo, kubandakanywa ezinye zitsalwe kwizityalo, kunye nokungcola okuthile okuveliswe kwi-chemical synthesis reaction. ukungcola okunokwenzeka.Kule nkqubo, ubuninzi kunye nohlobo lokungcola luhlala lutshintsha.Ngoko ke, i-semi-synthetic paclitaxel inokulawulwa okuphantsi kwizinto ezingcolileyo, kwaye ukungcola okutsha kufuneka kufundwe rhoqo kwinkqubo yokuvelisa.Ukungcola okuveliswa ngeenkqubo ezahlukeneyo zokuvelisa nazo nazo yahluke kakhulu, kwaye uhlalutyo oluthile luyafuneka.

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