I-Paclitaxel yinto ekhutshwe kwi-yew, enokuthi ithintele ngokufanelekileyo umhlaza kwaye lichiza lokulwa nomhlaza elisetyenziswa ngokubanzi kwihlabathi. Ngeminyaka yoo-1960, iikhemisti zaseMelika zahlukanisa i-taxol kwixolo le-Pacific yew, isityalo se-Taxus. Emva kweminyaka engaphezu kwama-20 uphando lwezonyango, inaliti yokuqala ye-paclitaxel "Taxol" yasungulwa ngo-1992. Ukuza kuthi ga ngoku,paclitaxelLelinye lamachiza aziwayo ebhotanical anti-tumor asebenza kakuhle. Ineempawu zokusebenza kakuhle, ubutyhefu obuphantsi kunye nobubanzi obubanzi. Ineziphumo ezicacileyo zonyango kumhlaza wesibeleko, umhlaza wamabele, imelanoma eyingozi, umhlaza wemiphunga, umhlaza wedlala lesinyi, ubuchopho. umhlaza kunye nomhlaza wesisu.
Iziphumo zovavanyo lwezonyango zibonisa ukuba, okwangoku, ukufunyanwa kwepaclitaxel APIsubukhulu becala kuxhomekeke ekutsalweni kwe Taxus chinensis izityalo kunye nemichiza Semisynthesis.Abaphandi zenzululwazi baqokelela amasebe alimiweyo kunye namagqabi Taxus chinensis chinensis, sebenzisa utsalo lokunyibilikisa, utsalo oluqinileyo isigaba, Supercritical ulwelo extraction, ulwahlulo membrane, ukwahlukana chromatographic kunye nezinye iindlela zokwahlula kunye nokutsalwa. khupha ii-precursors ezifana nesakhiwo se-paclitaxel, njenge-bacatine III, i-10 i-deacetyl bacatine III, njl.
Ngokwezibalo zenzululwazi, izigulane zomhlaza kufuneka zitye ngaphezu kwe-2 grams yepaclitaxelKwikhosi enye yonyango.Le mikhondo ye-paclitaxel kufuneka ikhutshwe kwi-bark ye-4-8 yemithi yasendle ye-Taxus chinensis ekhule ngaphezu kweminyaka engama-50. Kwelinye icala, i-Taxus chinensis kunye ne-paclitaxel zinqabile, kwaye kwelinye icala, kukho imfuno enkulu yonyango, ekhokelela kwixabiso eliphezulu lezinto ezikrwada zeTaxus chinensis unyaka wonke, kwaye unikezelo lusilela kwimfuno.
Ingcaciso:Ukusebenza okunokwenzeka kunye nokusetyenziswa okukhankanywe kweli nqaku zonke zivela kuncwadi olufumaneka esidlangalaleni.
Ufundo olwandisiweyo:Yunnan Hande Bio-tech ibandakanyeka ikakhulu ekutsalweni nasekuphuhliseni i-taxanes.Imveliso engundoqo yayo yindalo iPaclitaxel,10-DAB Semisynthesis Paclitaxel,10-DABIII,docetaxel,cabataxel, etc.Ukuba ufuna ukwazi malunga ne-paclitaxel esekwe imathiriyeli ekrwada, nceda uzive ukhululekile ukuqhagamshelana nathi.
Ixesha lokuposa: Jun-14-2023