Inkqubo yokuvelisa i-Paclitaxel, iyeza elisetyenziswa kakhulu kunyango lomhlaza, yinkqubo enzima kunye neyinkimbinkimbi ehlanganisa amanyathelo amaninzi, ukusuka ekutsalweni kwimithombo yendalo ukuya kwimiqulu yokugqibela yamayeza.Eli phepha liza kwazisa inkqubo yokuvelisapaclitaxel, ukusuka ekutsalweni ukuya ekulungiseleleni.
Inyathelo 1: Khupha
Paclitaxelyatsalwa ekuqaleni kwixolo lomthi wePasifiki, iTaxus pacifica.Inkqubo iqala ngokuqokelelwa kwamagxolo kwaye ngokuqhelekileyo idinga ukuphathwa ngokucophelela ukuphepha umonakalo emthini.Impahla yexolo eqokelelweyo iye yaphulwa kwaye ifakwe kwi-solvent efanelekileyo, njenge-ether okanye i-xylene.I-Paclitaxel inyibilika kwi-bark ibe yi-solvent kule nyathelo ukwenza isicatshulwa.
Inyathelo lesi-2: Ukwahlukana
Izicatshulwa zihlala ziqulethe iindidi ezahlukeneyo, ngoko ke i-paclitaxel kufuneka ihlulwe kwezinye iikhompawundi.Eli nyathelo lidla ngokusebenzisa ichromatographic chromatography okanye ezinye iindlela zokwahlula ukwahlula i-paclitaxel kwezinye izinto ezisekelwe kwiipropati zekhompawundi.
Inyathelo lesi-3: Ukucocwa
I-paclitaxel eyahlukanisiweyo kufuneka ihlanjululwe ngakumbi ukuze isuse nakuphi na ukungcola okuseleyo kwaye ifumane imveliso ecocekileyo kakhulu.Oku kubandakanya amanyathelo anje ngecrystallization, filtration, and recrystallization ukuqinisekisa ukuba i-paclitaxel yokugqibela inobunyulu obuphezulu.
Inyathelo lesi-4: Ukudibanisa (ukhetho)
Nangona i-paclitaxel yoqobo yakhutshwa kwimithombo yendalo, iinkampani ezininzi zamayeza ziye zavelisa iindlela zokuyidibanisa.Ezi ndlela zisebenzisa iindlela zeekhemikhali zokwenziwa ukwandisa isivuno kunye nokulawula kunye nokunciphisa ukuxhomekeka kwimithombo yendalo.
Inyathelo lesi-5: Lungisa iyeza
Isinyathelo sokugqibela kwinkqubo yokuvelisa kukulungiswa kwe-paclitaxel ecocekileyo ibe yilungiselelo lokusetyenziswa kwezonyango.Oku kunokubandakanya ukunyibilikisa i-paclitaxel kwisinyibilikisi esifanelekileyo, esifana notywala okanye i-ether, ukuyilungiselela kumalungiselelo amayeza.Eyona fomu ixhaphakileyo ilungiswa njengesisombululo esitofwayo sokuqinisekisa idosi echanekileyo.
Kuthathwe kunye, inkqubo yemveliso yepaclitaxelyinkqubo entsonkothileyo kunye namanyathelo amaninzi eyilelwe ukuqinisekisa ukucoceka okuphezulu kunye nokulawulwa kwechiza lokugqibela.Impumelelo yale nkqubo ibalulekile ekunikezelweni konyango olusebenzayo lomhlaza kwaye ke ngoko ihlala iphuculwa kwaye iphuculwa ukuhlangabezana neemfuno zonyango.
Qaphela: Iingenelo ezinokusetyenziswa kweli nqaku zifumaneka kuncwadi olupapashiweyo.
I-Yunnan Hande Biotechnology Co., Ltd. iye yagxila kwimveliso ye-paclitaxel iminyaka engama-26, kwaye ingumenzi ozimeleyo wezityalo ezikhutshwe kwi-anti-cancer drug paclitaxel API evunywe yi-United States FDA, i-EDQM yaseYurophu, i-Australia TGA, i-China CFDA. , I-Indiya, iJapan kunye nezinye ii-arhente zelizwe ezilawulayo.I-Yunnan Hande paclitaxel, indawo yokubonelela, ukuthengiswa ngokuthe ngqo kwefektri, wamkelekile ukubuza, 18187887160 (WhatsApp inani elifanayo)
Ixesha lokuposa: Oct-13-2023