Bonisa uhambo olunzima lwe-paclitaxel: ukusuka kwisicatshulwa sendalo ukuya kwi-synthetic enokwenzeka

I-Paclitaxel yimveliso yendalo ekhutshwe ekuqaleni kwi-bark ye-Pacific yew tree (Taxus pacifica) .I-biosynthesis ye-paclitaxel ibandakanya iindlela eziyinkimbinkimbi ze-biosynthetic, kubandakanywa ii-enzymes ezininzi kunye ne-intermediates. Umngeni kwimveliso yokwenyani yemizi-mveliso.Nantsi inkcazo jikelele ye-paclitaxel biosynthesis:

1. Izinto zokuqalisa: I-biosynthesis ye-paclitaxel iqala ngesixhobo sokuqala sendalo, esihlala sisuka emagqabini okanye kwixolo le-yew tree.

2.Multi-enzyme catalysis:Biosynthesis ofpaclitaxelifuna i-enzymes ezininzi ukuze i-catalyze reaction.Ezi enzymes ziguqula into yokuqala ibe yi-intermediates eyenza ngokuqhubekayo i-paclitaxel's precursor molecules.

I-3.I-Synthesis ye-intermediates: I-Intermediates yinyathelo eliphambili kwi-synthesis ye-paclitaxel.Ziquka i-polycyclic compounds kunye ne-side chain structures ezidityaniswe ngokuthe ngcembe ngokusebenzisa uchungechunge lwe-enzyme-catalyzed reactions.

I-4.I-synthesis yokugqibela ye-paclitaxel: Iimolekyuli ze-precursor ze-paclitaxel ze-synthesis ze-paclitaxel zixutywa ngokuthe ngcembe kwii-molecule ze-paclitaxel kumanyathelo okuphendula amaninzi.

5.Ukukhutshwa kunye nokuhlanjululwa: Emva kokuhlanganiswa kwe-paclitaxel, inyathelo lokutsalwa kunye nokucoca liyafuneka ukwahlula i-paclitaxel ecocekileyo kumxube wokuphendula.

Nangona iindlela zendalo ze-biosynthetic zepaclitaxelziye zafundwa, ukuveliswa kwangempela kwe-paclitaxel kuhlala kunzima kuba kufuna ukudibanisa okuyinkimbinkimbi kunye namanyathelo amaninzi kunye nobuninzi bezinto eziphathekayo. I-synthesis ye-paclitaxel ihlala ibandakanya indlela eyenziwe lula yokudibanisa ukunciphisa ubunzima.

Qaphela:Iinzuzo ezinokubakho kunye nezicelo ezichazwe kweli nqaku zithathwe kuncwadi olupapashiweyo.

I-Yunnan Hande Biotechnology Co.,Ltd.ijolise ekuvelisweni kwe-paclitaxel iminyaka engama-26, kwaye ingumenzi ozimeleyo wezityalo ezikhutshwe kwi-anti-cancer drug paclitaxel API evunywe yi-United States FDA,European EDQM,Australia TGA,China CFDA. ,Indiya,Japan kunye nezinye iiarhente zolawulo zelizwe.Yunnan Hande paclitaxel,spot supply,factory sales direct,wamkelekile ukubuza,18187887160(WhatsApp the same number)