Uphononongo ngempembelelo yonyango ye-paclitaxel kwiintlobo ezahlukeneyo zomhlaza

I-Paclitaxel yi-compound yendalo ekhutshwe kwisityalo se-yew, esinomsebenzi obalulekileyo wokulwa ne-tumor. Ekubeni i-paclitaxel yahlala yodwa kwi-bark ye-Pacific yew ngo-1971, uphando lwayo kwinkalo yonyango lomhlaza lube nomdla kakhulu. phonononga nzulu iziphumo zonyango lwepaclitaxelkwiindidi ezahlukeneyo zomhlaza.

Isakhiwo kunye neepropati ze-paclitaxel

I-Paclitaxel yi-compound ye-tetracyclic diterpenoid eyinkimbinkimbi kunye nesakhiwo esikhethekileyo se-dimensional ezintathu, esinika isiseko somsebenzi wayo wokulwa ne-tumor.Ifomula yayo ye-molecular yi-C47H51NO14, ubunzima be-molecular yi-807.9, kwaye yi-crystalline powder ekhanyayo kwiqondo lokushisa.

Indlela yokulwa nomhlazapaclitaxel

I-anti-cancer mechanism ye-paclitaxel inxulumene kakhulu nokuvinjelwa kwe-tubulin depolymerization kunye nefuthe layo kwi-cell division kunye nokwanda. Ukongeza, i-paclitaxel inokubangela i-apoptosis yeseli kwaye inqanda i-angiogenesis ye-tumor.

Impembelelo yonyango ye-paclitaxel kwiintlobo ezahlukeneyo zomhlaza

1. Umhlaza wamabele: Isiphumo sonyango se-paclitaxel kumhlaza wamabele sele samkelwa ngokubanzi. Kuphononongo lwezigulana zomhlaza wamabele ezingama-45, i-paclitaxel idityaniswe nechemotherapy ibangele ukushwabana kwethumba kwi-41% yezigulana kunye nokusinda okungaphezulu kweenyanga ezingama-20.

2. Umhlaza wemiphunga weseli engeyiyo encinci: Kumhlaza wemiphunga weseli ongeyonxalenye encinci, i-paclitaxel idityaniswe neplatinam-based chemotherapy drug inokuphucula kakhulu impilo yezigulana. ichemotherapy ibangele ukusinda kweenyanga ezili-12.

3. Umhlaza wesibeleko: Kunyango lwezigulane zomhlaza we-ovarian ezingama-70, i-paclitaxel edityaniswe neplatinam-based chemotherapy drug anciphisa amathumba kwi-76% yezigulana, kwaye izinga lokusinda leminyaka emibini lafikelela kuma-38%.

4. Umhlaza womqala: Kunyango lwezigulana ezingama-40 ezinomhlaza wommizo, i-paclitaxel idityaniswe neradiotherapy yanciphisa amathumba kwi-85% yezigulana, kwaye izinga lokusinda lonyaka omnye lifikelele kuma-70%.

5. Umhlaza wesisu: Kunyango lomhlaza wesisu, i-paclitaxel idityaniswe ne-fluorouracil inokuphucula kakhulu ukusinda kwezigulana. Kuphononongo lwezigulana ezingama-50 ezinomhlaza wesisu,paclitaxelkudityaniswe ne-chemotherapy kubangele ukusinda okuphakathi kweenyanga ze-15.

I-6. Umhlaza we-Colorectal: Kunyango lwe-30 yezigulane ezinomhlaza we-colorectal, i-paclitaxel idityaniswe ne-oxaliplatin yanciphisa amathumba kwi-80% yezigulane, kwaye izinga lokusinda leminyaka emibini lifikelele kwi-40%.

7.Umhlaza wesibindi:Nangona ifuthe le-paclitaxel monotherapy kumhlaza wesibindi lilinganiselwe, indibaniselwano yamanye amachiza e-chemotherapy afana ne-cisplatin kunye ne-5-fluorouracil inokuphucula kakhulu ukusinda kwezigulana. Uphononongo lwezigulane ezingama-40 ezinomhlaza wesibindi lubonise ukuba i-paclitaxel idibene. ngechemotherapy kubangele ukusinda kweenyanga ezili-9.

8. Umhlaza wezintso: Kunyango lomhlaza wezintso, i-paclitaxel edityaniswe neziyobisi ezikhusela umzimba ezifana ne-interferon-alpha inokuphucula kakhulu ukusinda kwezigulana. Iinyanga ezingama-24.

9. I-Leukemia: Kunyango lwe-acute myeloid leukemia, i-paclitaxel edityaniswe namachiza e-chemotherapy afana ne-cytarabine ingenza izigulana zifikelele kwizinga eliphezulu lokuxolelwa. kwi-80% yezigulane.

I-10, i-lymphoma: Kunyango lwe-non-Hodgkin lymphoma, i-paclitaxel edityaniswe namachiza e-chemotherapy afana ne-cyclophosphamide inokwenza izigulane zifikelele kwizinga eliphezulu lokuphendula. kwimpendulo epheleleyo kwi-85% yezigulane.

Ukuqukumbela

Isishwankathelo, i-paclitaxel ibonise ukusebenza kakuhle kunyango lweentlobo ezahlukeneyo zomhlaza. Nangona kunjalo, kubalulekile ukuqaphela ukuba ukusebenza konyango kuyahluka kuhlobo ngalunye lomhlaza kwaye luhlala lufuneka ngokudibanisa namanye amachiza. ukuntsonkotha kunye nokwahlukana komntu ngamnye komhlaza, izicwangciso zonyango kufuneka zenziwe ngesigulane ngasinye. Izifundo zexesha elizayo kufuneka zihlolisise amandla e-paclitaxel kunyango lomhlaza kunye nokwandisa ukusetyenziswa kwayo.

Qaphela:Iinzuzo ezinokubakho kunye nezicelo ezichazwe kweli nqaku zithathwe kuncwadi olupapashiweyo.