I-Paclitaxel yi-metabolite yesibini yendalo yodwa kwaye ihlanjululwe kwi-bark ye-fir ebomvu.Kuye kwaqinisekiswa ngokweklinikhi ukuba kunemiphumo emihle ye-anti-tumor, ngakumbi kwi-ovarian, uterine kunye ne-cancer yebele, eneziganeko eziphezulu zomhlaza.Ngoku,paclitaxel yendalokunye ne-semi-synthetic paclitaxel ziyafumaneka kwimarike.Inqaku elilandelayo liza kukuthatha kwindlela ye-paclitaxel synthesis.
Paclitaxelikhutshwe kwi-bark kunye namagqabi alo sityalo, kwaye inkqubo yokukhutshwa inzima kakhulu, ayinyibiliki emanzini kunye notywala, kwaye umxholo uphantsi kakhulu, kuphela i-100g, ie-taels ezimbini ze-paclitaxel, inokukhutshwa kwiitoni ezingama-30 zamagxolo omisiweyo. .Nangona i-chemical synthesis yayo iyonke igqityiwe kwilabhoratri, ibandakanya iinkqubo ezininzi, iimeko zokusabela ezinzima, iindleko eziphezulu kunye nesivuno esiphantsi.Ke ngoko, akukabikho nokwenzeka ukuba ivelise kwimizi-mveliso nge-chemical synthesis epheleleyo, eyenza ukuba ibize kakhulu.
Ukususela kwindalopaclitaxelIkhutshwe kwi-Pacific yew, engumthombo onqabileyo, kwaye umjikelo wokukhula we-yew yendalo ubude, malunga ne-13.6 kg yexolo ukukhupha i-1 gram ye-paclitaxel, kunye ne-3-12 yemithi ye-yew engaphezu kweminyaka eyi-100 ubudala iyadingeka ukunyanga i-ovarian enye. isigulana somhlaza, unikezelo lwexesha elide kunye nexabiso eliphezulu likhokelele kuphuhliso olukhawulezayo lwetekhnoloji yokwenziwa kwe-paclitaxel.
Okwangoku, eyona ndlela iphambili ye-paclitaxel synthesis yindlela ye-bioengineering, eyaziwa ngokuba yi-paclitaxel semisynthesis.Indlela ye-bioengineering isetyenziselwa ukuvelisa i-paclitaxel ngomlinganiselo omkhulu ngokuzala kunye nokukhangela iintlobo ezinokuvelisa inani elikhulu le-paclitaxel, kwaye emva koko ngokuqhubekayo ukulima, ukuguqula kunye nokuphucula isakhiwo sabo sofuzo, i-paclitaxel inokuveliswa kwindawo yenkcubeko "ngaphandle umda”, kwaye akusathintelwa kukunqaba kwemathiriyeli ekrwada.Iziphumo zophando zamva nje zibonisa ukuba ukusebenza kakuhle kwe-synthesis kuye kwaphuculwa kakhulu ngoxinzelelo lwemveliso ephezulu ye-448.52 micrograms ye-paclitaxel ngelitha yenkcubeko yenkcubeko.
I-Chemical synthesis, nangona igqityiwe, ayihambelani namashishini ngenxa yeemeko ezifunekayo, isivuno esiphantsi, kunye neendleko eziphezulu.Indlela ye-semi-synthetic ye-paclitaxel ngoku ikhulile kwaye ithathwa njengendlela esebenzayo yokwandisa umthombo we-paclitaxel ngaphandle kokulima okwenziwayo.Indlela ye-semi-synthetic inokusebenzisa kakhulu izibonelelo zezityalo.
Qaphela: Ukusebenza okunokwenzeka kunye nokusetyenziswa okuchazwe kweli phepha kubonakaliswe kuncwadi olupapashiweyo.
Ufundo olwandisiweyo:I-Yunnan Hande Biotechnology Co., Ltd. sele igxile kwimveliso ye-paclitaxel iminyaka eyi-28.Ngumvelisi wokuqala ozimeleyo wehlabathi we-anticancer drug paclitaxel evunywe yi-US FDA, i-European EDQM, i-Australian TGA, i-China CFDA, i-Indiya, i-Japan kunye nezinye ii-arhente ezilawulayo zelizwe.ishishini.Ukuba ufuna ukuthengaPaclitaxel API, nceda uqhagamshelane nathi kwi-intanethi.
Ixesha lokuposa: Oct-08-2022