Uphuhliso lwe-paclitaxel libali eligcwele ukujija kunye nokujika kunye nemingeni, eyaqala ngokufunyanwa kwezinto ezisebenzayo kwi-taxus taxus, yadlula amashumi eminyaka yophando kunye nophuhliso, kwaye ekugqibeleni yaba lichiza le-anticancer elisetyenziswa ngokubanzi kwiklinikhi.
Ngeminyaka yoo-1960, iZiko leSizwe loMhlaza kunye neSebe lezoLimo lase-US baye basebenzisana kwinkqubo yokuhlola isampuli yezityalo ukuze bafumane amachiza amatsha omhlaza.Ngo-1962, uBarclay, ingcaphephe yezityalo, waqokelela amaxolo kunye namagqabi kwilizwe laseWashington waza wawathumela kwi-NCI ukuze avavanyelwe umsebenzi ochasene nomhlaza.Emva koluhlu lwezilingo, iqela elikhokelwa nguGqr Wall kunye noGqr Wani ekugqibeleni bahlukanisa i-paclitaxel kwi-1966.
Ukufunyanwa kwe-paclitaxel kutsale ingqalelo ebanzi kwaye kwaqala uphando olukhulu kunye nenkqubo yophuhliso.Kwiminyaka elandelayo, izazinzulu zenze izifundo ezinzulu zesakhiwo sekhemikhali se-paclitaxel kwaye zamisela isakhiwo sayo se-molecular complex.Ngo-1971, iqela likaGqr.paclitaxel, ukubeka isiseko kwisicelo sayo seklinikhi.
I-Paclitaxel iqhube kakuhle kulingo lwezonyango kwaye iye yaba lunyango lokuqala lwebele kunye nomhlaza we-ovarian kunye nomhlaza wentloko, intamo kunye nemiphunga.Nangona kunjalo, izixhobo ze-paclitaxel zincinci kakhulu, ezithintela ukusetyenziswa kwayo kweklinikhi ebanzi.Ukuze kulungiswe le ngxaki, izazinzulu ziye zenza inani elikhulu lezifundo zokuhlola ukuhlanganiswa kwe-paclitaxel.Emva kweminyaka emininzi yemizamo, abantu baye baphuhlisa iindlela ezahlukeneyo zokudibanisa i-paclitaxel, kuquka i-synthesis epheleleyo kunye ne-semi-synthesis.
Kwixesha elizayo, uphando lwepaclitaxeliya kuqhubeka inzulu.Ngenkqubela phambili eqhubekayo yesayensi kunye netekhnoloji, abantu kulindeleke ukuba bafumane izinto ezininzi ze-bioactive ezinxulumene ne-paclitaxel kwaye baqonde ngakumbi indlela yokusebenza kwayo.Ngexesha elifanayo, kunye nophuhliso oluqhubekayo lweteknoloji ye-synthesis, i-synthesis ye-paclitaxel iya kusebenza ngakumbi kwaye ihambelana nokusingqongileyo, ukwenzela ukubonelela ngesiqinisekiso esingcono kwisicelo sayo seklinikhi ebanzi.Ukongeza, izazinzulu ziya kuphinda zihlolisise ukusetyenziswa kwe-paclitaxel ngokudibanisa namanye amachiza achasene nomhlaza ukubonelela ngeendlela zonyango ezisebenzayo.
Kufuphi,paclitaxelliyeza lendalo le-anticancer elinexabiso elibalulekileyo lonyango, kwaye uphando lwayo kunye nenkqubo yophuhliso igcwele imingeni kunye nempumelelo.Kwixesha elizayo, kunye nenkqubela phambili eqhubekayo yesayensi kunye nobuchwepheshe kunye nophando olunzulu, i-paclitaxel kulindeleke ukuba idlale indima ebalulekileyo kunyango lweentlobo ezininzi zomhlaza.
Qaphela: Iingenelo ezinokusetyenziswa kweli nqaku zifumaneka kuncwadi olupapashiweyo.
Ixesha lokuposa: Nov-13-2023