Ukulala yinxalenye ebalulekileyo yobomi bomntu bemihla ngemihla, enempembelelo ebalulekileyo kwimpilo yomntu ngamnye ngokomzimba nangokwengqondo, umsebenzi womzimba kunye nokusebenza kwengqondo.I-Melatonin, idlala elikhutshwa lidlala lepineal, linendima ebalulekileyo ekulawuleni isingqi sokulala nokugcina imeko yokulala.Eli nqaku liza kuphonononga impembelelo elawulayo ye-melatonin ebuthongweni ngokwembono yoncwadi lobuchwephesha.
Ubume kunye nomgaqo wokukhuselwa kwe-melatonin
I-Melatonin luhlobo lwehomoni ye-indole eyenziwe yaze yakhutshelwa lidlala lepituitary ledlala le-mammalian pineal, elinesingqisho esicacileyo.Kwindawo enokukhanya okwaneleyo, i-retina iva ukukhanya kwaye inqanda ukuhlanganiswa kwe-melatonin kunye nokukhutshwa kwe-retina-hypothalamic-pineal axis.Kwindawo emnyama, i-retina ayiziva ilula, kwaye ikhuthaza ukuhlanganiswa kunye nokukhuselwa kwe-melatonin nge-retina-hypothalamic-pineal axis.
Impembelelo ye-melatonin kumgangatho wokulala
I-Melatoninikhuthaza ukulala ngokuyintloko ngokusebenzisana ne-melatonin receptors ethile ukulawula iwotshi ye-circadian kunye nokuthintela ukuphaphama.Ebusuku, amanqanaba e-melatonin ayenyuka, enceda ukulungelelanisa iwotshi yebhayoloji yomzimba kwaye ilalise umntu.Kwangaxeshanye, imelatonin inokunceda ukugcina ubuthongo ngokucinezela ukuphaphama.Uphononongo lubonise ukuba impembelelo yokulawula ye-melatonin ebuthongweni inxulumene ngokusondeleyo nedosi kunye nexesha lolawulo.
Okwesithathu, ukuphazamiseka kwe-melatonin kunye nezifo ezinxulumene nokulala
Ukungasebenzi kakuhle kwe-melatonin kunokukhokelela kukuphazamiseka kokulala kunye nezinye iingxaki ezinxulumene nokulala.Ngokomzekelo, ukuphazamiseka kokulala okufana nokulala, i-shift syndrome, kunye nobunzima bokulungelelanisa kwi-jet lag kuhambelana nokuphazamiseka kwe-melatonin secretion rhythm.Ukongeza, ezinye izifundo zibonise ukuba ukuveliswa kwe-melatonin eyaneleyo kunokunyusa umngcipheko we-Alzheimer's disease, ukudakumba kunye nezinye izifo.
isiphelo
Indima ye-melatonin ekulawuleni ubuthongo ifundwe ngokubanzi kumanqanaba amaninzi.Nangona kunjalo, ngaphandle kwendima esekwe kakuhle ye-melatonin ekulawuleni ubuthongo, kusekho imibuzo emininzi efuna ukuphononongwa ngakumbi.Umzekelo, indlela ethile yokusebenza ye-melatonin isafuna ukufundwa ngakumbi;Impembelelo ye-melatonin kulawulo lokulala inokwahluka kubantu abahlukeneyo (njengabantu abaneminyaka eyahlukeneyo, isini kunye neendlela zokuphila).Kwaye uphonononge intsebenziswano phakathi kwe-melatonin kunye nezinye izinto zomzimba kunye nempilo yengqondo.
Ukongezelela, kubalulekile ukuqaphela ukuba nangona ukusetyenziswa kwe-melatonin ekulawuleni ukulala kubonisa ithemba elithembisayo, ukhuseleko lwayo, ukusebenza kakuhle kunye nokusetyenziswa ngokufanelekileyo kusafuna ubungqina obungakumbi bekliniki.Ke ngoko, izalathiso zophando lwexesha elizayo kufuneka zibandakanye ukwenza ulingo oluninzi lwezonyango ukuqinisekisa eyona mpembelelo ye-melatonin ekuphuculeni ubuthongo kunye nokuphazamiseka okunxulumene noko.
isalathiso
Bachman, JG, & Pandi-Perumal, SR (2012) .I-Melatonin: izicelo zeklinikhi ngaphaya kokuphazamiseka kokulala.I-Journal yophando lwepineal, i-52 (1), i-1-10.
Brayne, C., & Smythe, J. (2005) .Indima ye-melatonin ebuthongweni kunye nokubaluleka kwayo kweklinikhi.I-Journal yoPhando lwePineal, 39 (3),
Ixesha lokuposa: Sep-27-2023