Indima kunye nesiphumo sePaclitaxel

I-Paclitaxel lichiza elichasayo lomhlaza elinendlela eyodwa yokusebenza, esetyenziswa ngokubanzi kunyango lwezonyango ezahlukeneyo zomhlaza. Eli nqaku liza kubonelela ngolwazi oluthe kratya malunga nendima kunye nesiphumopaclitaxel,kubandakanya indlela yokusebenza kwayo, iziphumo ze-pharmacological, kunye nezicelo zeklinikhi.

Indlela yokwenza

Indlela yokusebenza ye-paclitaxel ikakhulu ukuthintela i-polymerization ye-microtubule protein, iphazamise inethiwekhi ye-microtubule kwiiseli, kwaye ngaloo ndlela inqanda ukwanda kweeseli kwaye ifake i-cell apoptosis.Iprotein ye-Microtubule yiprotheni ebalulekileyo kwinkqubo yokwahlulwa kweseli kunye nokwanda.I-Paclitaxel ingakwazi ibophelele kuyo kwaye ithintele umsebenzi wayo, ngaloo ndlela iphazamise inkqubo yokwahlulahlulwa kweeseli kunye nokwanda.Ukongezelela, i-paclitaxel inokulawula ukuphendula kwamajoni omzimba kwiiseli zethumba kunye nokuphucula amandla okulwa nethumba emzimbeni.

Iziphumo ze-Pharmacological

Kuvavanyo lwe-pharmacological,paclitaxelibonise umsebenzi obalulekileyo wokuchasa umhlaza kwaye inesiphumo esihle sonyango kwimihlaza eyahlukeneyo efana nomhlaza wamabele, umhlaza wesibeleko, umhlaza wemiphunga, njl.

Ukuthintela ukwanda kweeseli: I-Paclitaxel inokuthintela ukwanda kweeseli zethumba, ngakumbi ezo zikwisigaba se-mitotic.

Ukungeniswa kwe-apoptosis yeeseli: I-Paclitaxel inokulawula indlela ye-apoptosis yeeseli zethumba kwaye yenze i-apoptosis yeseli ye-tumor ifezekise injongo yokunyanga amathumba.

Ukomelezwa kwempendulo yokuzivikela komzimba: I-Paclitaxel inokulawula impendulo yokuzivikela kwiiseli ze-tumor kunye nokuphucula amandla omzimba wokulwa ne-tumor.

Izicelo zeklinikhi

I-Paclitaxel isetyenziswa kakhulu kunyango lwezonyango zomhlaza ezahlukeneyo, ezinjengomhlaza webele, umhlaza wesibeleko, umhlaza wemiphunga, njl. njl. Ukusebenza kwayo kwezonyango kuye kwaqatshelwa ngokubanzi kwaye iye yaba lelinye lamachiza abalulekileyo kunyango lomhlaza. idla ngokusetyenziswa ngokudibeneyo namanye amachiza echemotherapy ukuphucula isiphumo sonyango.

Iziphumo ezisecaleni ezinetyhefu

Iziphumo zecala ezinetyhefu ze-paclitaxel zisezantsi kakhulu, kodwa zisenokubangela iziphumo ezibi ezifana nokungaguquki komzimba, ukucinezelwa komongo wethambo, ubutyhefu bentliziyo, njl.n ukunyamezela iziyobisi ukunciphisa impembelelo yeziphumo ebezingalindelekanga eziyityhefu kwizigulana.

Amathuba oPhuhliso lwexesha elizayo

Ngenkqubela phambili eqhubekayo yesayensi kunye neteknoloji kunye nophando olunzulu malungapaclitaxel,uphando lwexesha elizayo kwi-paclitaxel luya kuba lubanzi kwaye lunzulu.Ngaphezu kokuqhubeka nokuphonononga indlela yokulwa nomhlaza, uphando olongezelelweyo luya kuqhutywa ukuphucula umphumo wonyango we-paclitaxel kunye nokunciphisa iziphumo zayo ezinetyhefu. ixesha, ngophuhliso lobuchwepheshe obuvelayo obufana nobunjineli bemfuza kunye nonyango lweseli, izicwangciso zonyango ezilungiselelwe wena ze-paclitaxel nazo ziyakwenzeka, zibonelela ngeendlela zonyango ezichaneke ngakumbi nezisebenzayo kwizigulana ezinomhlaza.

Ukuqukumbela

I-Paclitaxel lichiza elibalulekileyo elichasene nomhlaza kunye nezicelo zeklinikhi ezibanzi. Isiphumo salo esibalulekileyo sonyango kunye neziphumo ezibi eziphantsi ezinetyhefu zenza kube lukhetho olubalulekileyo kunyango lwezomhlaza ezahlukeneyo. Uphando lwexesha elizayo kwi-paclitaxel luya kuba nzulu kwaye lugqibelele ukubonelela ngokungcono. iindlela zonyango kunye nethemba lokusinda kwizigulane ezinomhlaza.