Indlela eyahlukileyo yokuLwa neTumor yePaclitaxel

I-Paclitaxel liyeza eligqwesileyo lendalo elichasene nomhlaza elifunyenwe ngoku, lisetyenziswa kakhulu kunyango lomhlaza we-ovarian, umhlaza wamabele, umhlaza wemiphunga, amathumba entloko kunye nentamo, umhlaza wommizo, umhlaza wesisu kunye ne-sarcoma yezicubu ezithambileyo.Paclitaxelitsale umdla omkhulu kwizazinzulu ngenxa yobume bayo bekhemikhali entsonkothileyo kunye nenoveli, iindlela ezizodwa zebhayoloji zokwenza, umsebenzi othembekileyo wokulwa nomhlaza, kunye nokunqongophala okukhulu kwezixhobo. Ngokwezibalo, ngaphezulu kwe-30 iilabhoratri eziphezulu kwihlabathi jikelele ziye zabandakanyeka kuphando lweTotal. I-synthesis ye-paclitaxel, kwaye ukhuphiswano lubukhali kakhulu, oluye lwaba lugxininiso lwe-organic synthetic chemistry ngasekupheleni kwenkulungwane yama-20.

Indlela ekhethekileyo yokulwa ne-tumor ye-paclitaxel

I-Paclitaxel inokwenza i-Tubulin kunye ne-Tubulin dimer eyenza i-microtubules ilahlekelwe yi-Dynamic equilibrium, ikhuthaze kwaye ikhuthaze i-Tubulin polymerization, indibano ye-microtubule, kwaye ithintele i-depolymerization, ukuze kuzinziswe ii-microtubules kunye nokuthintela i-Mitosis yeeseli zomhlaza kunye nokubangela i-apoptosis, ngaloo ndlela ithintele ngokufanelekileyo ukwanda komhlaza. iiseli kunye nokudlala indima echasene nomhlaza.

Enyanisweni, i-Tubulin, enxulumene ngokusondeleyo ne-cell Mitosis, ikhona phantse jikelele kuzo zonke iiseli ze-eukaryotic. Ziyakwazi ukupholisa kwi-microtubules ngokuguqukayo. Ukuqhekeka kwehamile njenge-microtubules kunokuzikhethela ngokubulala iiseli ezinokwahlukana okungaqhelekanga.Amanye amachiza abalulekileyo achasene nomhlaza, njenge-colchicine, i-Vinblastine, i-Vincristine, idlala indima ye-anti-tumor ngokuthintela i-Tubulin kwi-polymerization.

Ngokuchasene ne-anti-Mitosis kunye neziyobisi ezichasayo,paclitaxellichiza lokuqala elifunyenweyo elinokuthi lisebenze kunye ne-Tubulin polymer, oko kukuthi, lisebenza ngokudibanisa ngokusondeleyo kunye ne-microtubules ukubenza bazinze.Ngexesha elifanayo, kufunyenwe ukuba i-paclitaxel ibonisa iziphumo ezilungileyo kwiindidi ze-tumor cells eziqinileyo.Le entsha ukufunyanwa kuye kwatsala iingcali zebhayoloji ezininzi ukuba zisebenzisepaclitaxelnjengesixhobo sophando kwi-biomedicine, ukuhlola iindawo ezingaziwayo zomsebenzi weeseli kunye nokufumanisa iindlela ezintsha zamachiza e-anticancer.

Ingcaciso:Ukusebenza okunokwenzeka kunye nokusetyenziswa okukhankanywe kweli nqaku zonke zivela kuncwadi olufumaneka esidlangalaleni.

I-Yunnan Hande Bio-tech igxile kwimveliso ye-paclitaxel iminyaka engama-28.Yishishini lokuvelisa elizimeleyo le-paclitaxel izinto eziluhlaza, ezivunyiweyo ngamaziko alawulayo kazwelonke afana ne-FDA e-United States, i-EDQM eYurophu, i-TGA e-Australia, i-CFDA e-China, i-Indiya, ne-Japan.Yunnan Handepaclitaxelifumaneka kwisitokhwe kwaye ithengiswa ngokuthe ngqo ngabavelisi.Wamkelekile ukubuza.