Siyazi ukuba iintlobo ze-paclitaxel ezithengisiweyo ziquka inaliti ye-paclitaxel, i-liposomal paclitaxel, i-docetaxel, kunye ne-albumin-bound paclitaxel.Zeziphi izinto eziluncedo kwipaclitaxel esanda kuthengiswa kunye ne-paclitaxel polymer micelles?Makhe sijonge oku kulandelayo.
Izinto ezilungileyo ze-paclitaxel polymer micelles
1. I-copolymer ihlangene ngokwayo emanzini ukwenza i-nanocarrier kunye nesakhiwo se-"core-shell".I-nuclear encapsulated paclitaxel ye-micelle ayithotywanga, ukuze ikwazi ukudlala indima egazini ixesha elide.
2. I-polymer micellar paclitaxel particles zincinci kakhulu (18-20nm), ezinokujoliswa ngokungaqhelekanga kwi-tumor microenvironment ene-vascular disorders.Ngale ndlela, iyeza lihlala lihlala kwizicubu zethumba, okukhokelela ekugxininiseni okuphezulu kwizicubu zethumba kunye noxinzelelo oluphantsi kwizicubu eziqhelekileyo.Ngelixa kuphuculwe ukusebenza kakuhle, izehlo zeziphumo ebezingalindelekanga ziyancipha ngakumbi.
Ukusetyenziswa kwe-paclitaxel polymer micelles e-china
Ngo-Okthobha ka-2021, i-China National Drug Administration (NMPA) yabhengeza ukuba i-polymer micelle yokuqala ye-paclitaxel e-China yamkelwe, kwaye umqondiso wawungowona mhlaza wemiphunga omncinci.
Qaphela: Ukusebenza okunokwenzeka kunye nezicelo eziveliswe kweli nqaku zonke zivela kuncwadi olupapashiweyo.
I-Yunnan Hande Biotechnology Co., Ltd ibisebenza ngokukhethekileyo kwimveliso yepaclitaxel APIngaphezu kweminyaka engama-20, kwaye yenye yabakhiqizi abazimeleyo behlabathi be-paclitaxel API, ichiza eliphuma kwisityalo elichasene nomhlaza, elivunywe yi-US FDA, i-European EDQM, i-Australian TGA, i-CFDA yaseTshayina, i-India, iJapan kunye nezinye ii-arhente ezilawulayo zelizwe. .I-Hande inokubonelela kuphela ngomgangatho ophezulupaclitaxel imathiriyeli ekrwada, kodwa kunye neenkonzo zophuculo lobugcisa ezinxulumene nokuqulunqwa kwe-paclitaxel.Ngolwazi oluthe vetshe, nceda ukhululeke ukunxibelelana nathi apha 18187887160.
Ixesha lokuposa: Dec-15-2022