Yintoni i-albumin-bound paclitaxel?

Yintoni i-albumin-bound paclitaxel?I-Albumin-bound paclitaxel (eyaziwa ngokuba yi-albumin paclitaxel, ekwafinyezwa njenge-Nab-P) yi-paclitaxel nanoformulation entsha, eyaziwa kwihlabathi njengeyona ndlela iphambili yokwenziwa kwe-paclitaxel.Idibanisa i-albumin yabantu engapheliyo kunye ne-paclitaxel kwifom engabonakaliyo kunye ne-nanoparticles ebangelwayo yoyisa ngokupheleleyo i-didvantage ye-paclitaxel enganyibiliki emanzini, ngaphandle kwesidingo se-polyoxyethylene ioli ye-castor okanye i-Tween 80 njenge-co-solvent.Njengoko i-albumin iyimveliso yendalo engapheliyo, ineenzuzo zokukhuseleka, ezingenayo ityhefu, i-non-immunogenic, i-biodegradable, kunye ne-biocompatible.

Kutheni le nto i-albumin-bound paclitaxel iyeyona iphambili?

1. Akukho co-solubilizationno pre-unyango

Ukwamkela iprotein ye-plasma yemvelaphi yendalo, ibophelela iimolekyuli ze-hydrophobic paclitaxel kwifom e-non-covalent ngaphandle kwe-co-solvent, isusa i-hypersensitivity kunye ne-toxic reactions ebangelwa yi-co-solvents, ngaloo ndlela isusa isidingo sokunyangwa kwangaphambili kwehomoni ngaphambi kokusetyenziswa kunye nokunciphisa ixesha lokuxhamla. ukuya kwimizuzu engama-30, inciphisa kakhulu ukuhlala esibhedlele kwezigulana ze-oncology, kunye nokugqiba ichemotherapy ngekliniki yasemini.

2. I-pharmacokinetics engcono

Xa kuthelekiswa ne-paclitaxel eqhelekileyo, i-albumin paclitaxel inokusasazwa ngokukhawuleza kunye nokuphezulu kwezicubu emzimbeni, kunye nokukhupha ngokukhawuleza kwizicubu, umthamo onyamekileyo emzimbeni womntu unokunyuswa kakhulu kwaye umphumo wonyango uphuculwe kakhulu.

3. Ukuhlanganiswa kwethumba lendawo elikhethiweyo

Esinye sezizathu zokuba kutheni izigulane ezininzi zoyika i-paclitaxel chemotherapy kukuba ukuhanjiswa kwe-paclitaxel yendabuko kwizicubu ze-tumor kunye nezinye izihlunu eziqhelekileyo ziyafana, kubangela iziphumo ezibi kakhulu.Ngokwahlukileyo koko, i-paclitaxel inommangaliso "wokutyebisa ithumba lendawo" kwaye ukugxila kwayo kwizicubu zethumba kuphezulu kakhulu kunokwezinye izihlunu eziqhelekileyo.

Qaphela: Iziphumo ezinokubakho kunye nezicelo ezichazwe kweli nqaku zithathwe kuncwadi olupapashiweyo.

I-Yunnan Hande Bio-Tech Co., Ltd ibe yinto ekhethekileyo kwimveliso yepaclitaxel APIngaphezu kweminyaka engama-20, kwaye yenye yabakhiqizi abahamba phambili behlabathi be-paclitaxel API ngokuvunywa kwe-FDA, isatifikethi se-CEP kunye nesiqinisekiso se-GMP e-China.I-Hande inokubonelela nge-paclitaxel API ekumgangatho ophezulu kuphela kodwa nayoinkonzo yokudlulisa iteknoloji ye-albumin ye-paclitaxel.Ngolwazi oluthe vetshe, nceda ukhululeke ukunxibelelana nathi apha 18187887160.