Yintoni iSemi-synthetic Paclitaxel?

Yintoni iSemi-synthetic Paclitaxel?I-Semi-synthetic Paclitaxellichiza elisetyenziselwa ukunyanga iintlobo zomhlaza.Yinguqulelo eyenziweyo eyenziweyo ye-paclitaxel, esetyenziswa ngokubanzi kunyango lwezonyango ngenxa yempembelelo yayo yokuthintela kwiiseli zomhlaza.

I-Paclitaxel yi-compound yendalo ekhutshwe kwimithi ye-Yunnan fir, enezinto ezichasayo ze-tumor.Nangona kunjalo, ngenxa yomthombo oqingqiweyo we-paclitaxel kunye nesakhiwo sayo esiyinkimbinkimbi, i-synthetic Semi-synthetic Paclitaxel iye yaba yi-substitute.Semisynthesis taxol ifunyenwe ngokukhupha iikhompawundi ezifanayo. ukusuka kwezinye izityalo, kwaye emva koko ngokusabela kweekhemikhali kunye nokuguqulwa.

Inkqubo yokulungiselela i-Semi-synthetic Paclitaxel inzima kakhulu kwaye ifuna i-multi-step reaction.Okokuqala, iikhompawundi ezifanayo zikhutshwa kwizityalo kwaye ziguqulelwe kwi-precursors ye-paclitaxel ngokusebenzisa iikhemikhali. iguqulelwe kwi-Semi-synthetic Paclitaxel.Ekugqibeleni, i-Semi-synthetic Paclitaxel yahlanjululwa yaza yakhazimliswa ukuze ifumane amayeza acocekileyo.

I-Semi-synthetic PaclitaxelIbonise iziphumo ezilungileyo kunyango lwezomhlaza ezahlukeneyo. Inokuthintela ukukhula kunye nokusasazeka komhlaza ngokuphazamisa inkqubo yeMitosis yeeseli zethumba. Ukongeza, iSemi-synthetic Paclitaxel inokuphucula ukusebenza kweradiotherapy kunye nechemotherapy, kwaye inciphise ukungaphatheki kakuhle kwezigulane.

Ukuququmbela,I-Semi-synthetic Paclitaxelliyeza elibaluleke kakhulu elichasene nomhlaza.Nangona inkqubo yalo yokulungiselela intsonkothile, isiphumo sayo sonyango sibaluleke kakhulu.Ngenkqubela phambili eqhubekayo yesayensi kunye nobuchwepheshe, kukholelwa ukuba i-Semi-synthetic Paclitaxel iya kudlala indima ebaluleke ngakumbi kunyango lwexesha elizayo. .