Uthini umahluko phakathi kweentlobo ezine ze "paclitaxel"?

I-Paclitaxel, ekwabizwa ngokuba yi-paclitaxel ebomvu, i-tamsulosin, i-violet, kunye ne-tesu, lelona chiza libalaseleyo lokulwa nomhlaza elifunyenwe ukuza kuthi ga ngoku, kwaye lisetyenziswe ngokubanzi kunyango lwezonyango lomhlaza wamabele, umhlaza wesibeleko, kunye nomhlaza wentloko kunye nentamo kunye nomhlaza. umhlaza wemiphunga. Njengeyeza lekhemotherapy yakudala, igama likapaclitaxelkukholelwa ukuba abantu abaninzi bavile ngayo.Makhe sijonge umahluko phakathi kweentlobo ezine zepaclitaxel kwinqaku elilandelayo.

Umahluko phakathi kweentlobo ezine zepaclitaxel

1, I-Paclitaxel: Isebenza kwinkqubo yeprotheyini ye-microtubule / microtubule, inqanda i-microtubule depolymerization, ibhloka umjikelo weseli kwisigaba se-G2 / M, ikhokelela kwi-mitosis engaqhelekanga okanye ukubanjwa, ithintela ukuphindaphinda kweseli yethumba, kwaye yenza iiseli zomhlaza zingakwazi ukuqhubeka nokwahlula kunye nokufa.

2, I-Docetaxel: Indlela yokusebenza iyafana naleyo ye-paclitaxel, kodwa ngokuhambelana okuphezulu kwindawo yokubopha i-microtubule kunye nomsebenzi ophezulu wokuchasana nomhlaza.

I-3, i-Liposomal paclitaxel: Indlela yokusebenza iyafana naleyo ye-paclitaxel.I-liposomes yenziwe yi-lecithin, i-cholesterol, i-threonine kunye nezinye izinto ezifana ne-phospholipid ngaphandle kwesakhiwo se-cell membranes encapsulate paclitaxel, enokuphucula ukunyibilika kwamanzi, ukungena lula. kwizicubu zethumba ukusuka kwimithambo yegazi, kunye nokunciphisa ubutyhefu bentliziyo kunye nezintso, njl.

I-4.Albumin-bound paclitaxel:i-hydrophobic paclitaxel idityaniswe ne-serum ye-albumin carrier nge-nanotechnology.I-Albumin inokunyusa ukunyuswa kwe-paclitaxel kwi-tumor ngokuzibophelela kwi-gp60 receptor kunye nokwandisa ukuxinwa kwe-paclitaxel kwizicubu ze-tumor, ngaloo ndlela inyusa i-anti-tumor effect. .

Zombini i-paclitaxel, i-doxorubicin, i-paclitaxel liposome okanye i-albumin paclitaxel luhlobo olufanayo lweziyobisi ze-chemotherapeutic, kwaye zonke zezodidi lwe-paclitaxel kuhlelo lwamachiza e-chemotherapeutic. Ziluhlobo olufanayo lwechiza.I-Paclitaxel lichiza le-antitumor elinomgaqo we-microtubule inhibitor, esetyenziswa ngokubanzi kwichemotherapy cancer cancer.

Qaphela:Ukusebenza okunokubakho kunye nokusetyenziswa okugutyungelwe kulo mboniso kuthatyathwe kuncwadi olupapashiweyo.

Ufundo olwandisiweyo:I-Yunnan Hande Biotechnology Co., Ltd. sele igxile kwimveliso ye-paclitaxel iminyaka eyi-28.Ngumvelisi wokuqala ozimeleyo wehlabathi we-anticancer drug paclitaxel evunywe yi-US FDA, i-European EDQM, i-Australian TGA, i-China CFDA, i-Indiya, i-Japan kunye nezinye ii-arhente ezilawulayo zelizwe.ishishini.Ukuba ufuna ukuthengaPaclitaxel API, nceda uqhagamshelane nathi kwi-intanethi.