Yintoni uBudlelwane phakathi kwePaclitaxel kunye nePaclitaxel yokuSuspension okuTofwayo(i-Albumin Bound)?

Yintoni i-paclitaxel, i-paclitaxel ye-injectable suspension kunye ne-albumin-bound paclitaxel? Zeziphi ezona zinto zisetyenziswayo? Siza kuzichaza ngokufutshane kweli nqaku.

Paclitaxel:

I-metabolite yesibini yendalo eyodwa kwaye ihlanjululwe kwi-bark, amasebe kunye namagqabi e-gymnospermous taxus chinensis inokukhuthaza i-polymerization ye-microtubule kunye nokuzinzisa i-polymerized microtubules. ngemisebenzi eyahlukeneyo yeeseli, ngakumbi ukumisa ulwahlulo lweeseli kwinqanaba le-mitotic, kwaye ithintele ulwahlulo lweeseli oluqhelekileyo.

Inesiphumo esihle sokulwa ne-tumor kwaye isetyenziselwa ukunyanga umhlaza webele ophezulu, umhlaza wemiphunga, umhlaza wesibeleko, umhlaza wentloko kunye nentamo, umhlaza wezicubu ezithambileyo kunye nomhlaza wokugaya ukutya.

I-Paclitaxel (i-Taxol) yi-API ye-anticancer (I-Active Pharmaceutical Ingredient), engenakusetyenziswa ngokuthe ngqo ngabantu.Idinga ukunikezelwa kwiinkampani ezisezantsi okanye iifektri zamachiza ukuba ibe enye ye-API yamachiza agqityiweyo.

Okwangoku, eyona isetyenziswa kakhulu kwi-paclitaxel yinaliti ye-anticancer kunye nezixhobo zonyango (kubandakanywa i-stents kunye neebhaluni). Ngophuhliso olukhawulezayo lwe-biotechnology kunye nobuchwepheshe bezonyango, ukusetyenziswa kwe-paclitaxel kusoloko kuphononongwa, kwaye iimeko ezahlukeneyo zezigulane nazo zikwanjalo. Kholelwa ukuba kwixesha elizayo elingekude, kuya kukhuseleka kwaye kulunge ngakumbi kunyango loogqirha kunye nezigulane, kwaye kuya kubakho iintlobo ezininzi zamachiza e-anticancer aqukethe i-paclitaxel kunye nefuthe elinamandla le-anticancer.

I-Paclitaxel ye-Injectable Suspension:

Isitofu esiqulethe i-paclitaxel API.

I-Paclitaxel yenaliti ikwabandakanya inaliti ye-polyoxyethylene castor yeoli ye-paclitaxel; inaliti ye-Liposome paclitaxel; inaliti ye-albumin ebotshwe kwi-paclitaxel; I-Micellar paclitaxel kunye nezinye iifom zedosi.

Isetyenziswa kakhulu kumhlaza wamabele, umhlaza wemiphunga, umhlaza wesibeleko kunye nezinye izifo, kwaye lelinye lawona machiza asebenzayo ngoku.

I-Albumin iBond Paclitaxel:

Inaliti ye-albumin ebotshiweyo ye-paclitaxel lulungiselelo oludibanisa i-paclitaxel kunye ne-albumin.Yeye-paclitaxel yokutofa kwaye yenye yezona zisetyenziswa ngokubanzi kwi-paclitaxel ye-paclitaxel enokhuseleko oluphezulu.

I-Albumin paclitaxel, eyokuqala ukungena emehlweni abantu yi-ABRAXANE Injection(ABRAXANE ye-Injectable Suspension paclitaxel-bound particles protein-bound for injectable suspension,albumin-bound) evunywe yi-FDA ngo-2005, esetyenziselwa ukunyanga umhlaza webele we-metastatic. ukuchithwa kwakhona kumalunga ne-130 nm, kwaye ayiqulathanga izinyibilikisi eziyityhefu. Isiphumo sokhuseleko salo kunye nesiphumo sonyango siphezulu kakhulu kuneso samalungiselelo afanayo, kwaye sithandwa kakhulu. Kwakhona sesinye sezizathu eziphambili zophando kunye nokulinganisa. yamashishini amakhulu axuba amayeza kwixesha elizayo.

Isebenza ikakhulu kunyango lomhlaza webele we-metastatic ongaphumeleliyo kwi-chemotherapy edibeneyo okanye umhlaza wamabele ophinda ubuyele phakathi kweenyanga ze-6 emva kwe-adjuvant chemotherapy.

UYunnan Hande Bio-Tech uzibophelele kuphando nophuhliso kunye nokuveliswa kwepaclitaxel,docetaxel,I-10-DAB semi-synthetic paclitaxel, kwayecabazitaxelUkongeza, i-Hande ikwabonelela ngeenkonzo zodluliselo lobuchwephesha ezinxulumene ne-paclitaxel: iinaliti ze-paclitaxel zesintu; iinaliti ze-albumin ezibotshwe kwi-paclitaxel njl.njl, wamkelekile ukuba uqhagamshelane nathi ukubuza! (Whatsapp/Wechat:+86 18187887160