IGlabridin isuka kwisityalo iGlycyrrhiza glabra, ikhona kuphela kwingcambu kunye nesiqu seGlycyrrhiza glabra(Eurasia), kwaye yeyona nto iphambili ye-Isoflavone yeGlycyrrhiza glabra.Glabridininomhlophe, i-antioxidant, i-anti-inflammatory kunye nezinye iziphumo.Ngenxa yomxholo ophantsi we-glabridin kunye nobunzima benkqubo yokucoca, inesihloko esithi "igolide emhlophe".
1, Umgaqo mhlophe Glabridin
Ngaphambi kokuba siqonde umgaqo omhlophe we-glabridin, kufuneka siqale siqonde ngokufutshane izizathu zokuvelisa i-melanin.
Ukwenziwa kwemelanin kufuna izinto ezintathu ezisisiseko:
Tyrosine:Esona sixhobo siphambili sokuvelisa imelanin.
I-Tyrosinase: isantya esiphambili sokunciphisa i-enzyme eguqula i-tyrosine ibe yi-melanin.
Iintlobo zeoksijini esebenzayo:ITyrosine kufuneka idityaniswe neoksijini kwinkqubo yokuvelisa imelanin phantsi kwentshukumo yeTyrosinase.
I-Tyrosinase inokuvelisa i-melanin rhoqo.I-stimuli yangaphandle (kubandakanywa imitha ye-ultraviolet eqhelekileyo, ukuvuvukala, i-allergies, njl.njl.) inokukhokelela ekukhupheni okugqithisileyo, okukhokelela ekubeni mnyama.
Kwangaxeshanye, iintlobo zeoksijini esebenzayo (i-ROS) ebangelwa yimitha ye-ultraviolet inokonakalisa inwebu ye-phospholipid yezicubu zolusu, ebonakala njenge-erythema kunye ne-pigmentation eluswini. isizukulwana sayo sinokunqanda ukuveliswa kwe-melanin kunye ne-pigmentation.
2, Izibonelelo ezimhlophe zeGlabridin
Ngokufutshane, inkqubo yokwenza mhlophe kunye nokukhanya kwamabala yinkqubo yokulwa neTyrosinase kunye neentlobo zeoksijini ezisebenzayo.
IGlabridin ikakhulu inqanda umsebenzi weTyrosinase ngokukhuphisana kwezesondo, ithatha inxenye yeTyrosinase kude neringi ye-melanin synthesis, inqanda indibaniselwano ye-substrate kunye neTyrosinase, ngaloo ndlela inqanda ukuhlanganiswa kwe-melanin.iglabridinngokwayo ineempembelelo ezilungileyo ze-antioxidant kunye ne-anti-inflammatory.
Ukushwankathela,iglabridinikakhulu inqanda i-melanogenesis ngeendlela ezintathu: inqanda umsebenzi weTyrosinase, inqanda ukuveliswa kweentlobo zeoksijini esebenzayo, kwaye inqanda ukudumba.
Iimvavanyo zibonise ukuba kukukhawuleza, okusebenzayo, kunye nokumhlophe okuluhlaza kunye ne-freckle esusa i-cosmetic additive.Kukho idatha yovavanyo ebonisa ukuba umphumo wobumhlophe we-Glabridin ngamaxesha angama-232 we-vitamin C eqhelekileyo, amaxesha angama-16 aphezulu kune-hydroquinone (quinone), kunye 1164 amaxesha e "arbutin".
Ingcaciso:Ukusebenza okunokwenzeka kunye nokusetyenziswa okukhankanywe kweli nqaku zonke zivela kuncwadi olufumaneka esidlangalaleni.
Ixesha lokuposa: Jun-28-2023