Kutheni le nto i-albumin-bound-bound paclitaxel ingafuneki ukuba yenziwe ngaphambili?

Okwangoku, kukho iindidi ezintathu zamalungiselelo e-paclitaxel kwimarike e-China, kubandakanywa inaliti ye-paclitaxel, i-Liposomal paclitaxel kunye ne-Albumin-bound paclitaxel. ibotshiwe i-paclitaxel ayifuni kunyangwa?Makhe sijonge oku kulandelayo.

Kutheni le nto i-Albumin-bound bound paclitaxel ingafuneki ukuba yenziwe ngaphambili?

1.Inaliti yePaclitaxel

Ukwandisa ukunyibilika kwamanzi kwi-paclitaxel, i-solvent ye-paclitaxel yenaliti yenziwe nge-polyoxyethylene castor oil kunye ne-ethanol. kwaye kubangele ukungezwani komzimba.Ngaphambi kokusetyenziswa kweklinikhi, i-glucocorticoids kunye ne-antihistamines kufuneka zisetyenziswe ukunyanga kwangaphambili.

2.Liposomal paclitaxel

I-Liposomal paclitaxel ikakhulu i-phospholipid bimolecular liposomes kunye nobubanzi be-400 nm eyenziwe yi-lecithin kunye ne-cholesterol kwi-proportion ethile.Ayiqukethe ioli ye-polyoxyethylene ye-castor kunye ne-ethanol epheleleyo enokubangela ukungahambi kakuhle.

Nangona kunjalo, olunye uphononongo lubonise ukuba i-paclitaxel ngokwayo inokubangela u-hypersensitivity, nto leyo enxulumene nokusebenza kweendlela zokuzivikela ezikhuselweyo zi-basophils, i-IgE kunye ne-IgG. Ifuna unyango lwangaphambili lwe-aleji phambi kokusetyenziswa.

3.I-Albumin-bound paclitaxel

I-Albumin-bound paclitaxel, ene-albumin yomntu njengomthwali, ineengenelo zokubola lula kwi-vivo, ukuqokelelwa kwamachiza amaninzi kumathumba, ukujoliswa okuqinileyo kunye nokusebenza okuphezulu kwechemotherapy.

KwiSigaba se-I, II okanye kwizifundo ze-III kwi-albumin-bound paclitaxel, nangona kungakhange kuqhutywe ngaphambili, akukho mpendulo ye-hypersensitivity enzima yafunyanwa. .Ngoko ke, unyango lwangaphambi kokulawulwa kwe-albumin ebotshwe i-paclitaxel ayikhuthazwa okwangoku.

Qaphela:Ukusebenza okunokwenzeka kunye nezicelo eziveliswe kweli nqaku zonke zivela kuncwadi olupapashiweyo.

I-Yunnan Hande Biotechnology Co., Ltd ibigxile ekuvelisenipaclitaxel APIngaphezulu kweminyaka engama-20, kwaye ngomnye wabavelisi behlabathi abazimeleyo be-paclitaxel API, ichiza eliphuma kwisityalo elichasene nomhlaza, elivunywe yi-US FDA, i-European EDQM, i-Australian TGA, iCFDA yamaTshayina, iIndiya, iJapan kunye nezinye iiarhente ezilawula ilizwe. .I-Hande ayinikezeli kuphela umgangatho ophezulupaclitaxel imathiriyeli ekrwada,kodwa kunye neenkonzo zophuculo lobugcisa ezinxulumene ne-paclitaxel formulation.Ngolwazi oluthe kratya, nceda uzive ukhululekile ukuqhagamshelana nathi ku-18187887160.