Umahluko kunye neenzuzo phakathi kwe-paclitaxel yendalo kunye ne-semi-synthetic

I-Paclitaxel lichiza elibalulekileyo le-anticancer, kwaye isakhiwo sayo esisodwa kunye nomsebenzi webhayoloji utsale ingqalelo enkulu kwizazinzulu.Ngokomthombo wayo kunye nendlela yokulungiselela, i-paclitaxel inokohlulwa ibe yi-paclitaxel yendalo kunye ne-semi-synthetic paclitaxel.Eli nqaku liza kuxubusha iiyantlukwano kunye neenzuzo kwezi zimbini.

Umthombo kunye nendlela yokulungiselela

I-paclitaxel yendalo:I-paclitaxel yendalo itsalwa ikakhulu kumthi we-Pacific yew(Taxus brevifolia).Lo mthi utyebile nge-paclitaxel,kodwa ngokwezixa ezinyiniweyo,ukwenza ubonelelo lwe-paclitaxel yendalo lunqongophele.

I-semi-synthetic paclitaxel:I-Semi-synthetic paclitaxel idityaniswe yi-chemical synthesis evela kwi-taxane ekhutshwe kwi-bark ye-taxus chinensis.Le ndlela ingasetyenziselwa ukuvelisa i-paclitaxel kwizinga elikhulu ukuhlangabezana neemfuno zekliniki.

Ubume beMichiza

Nangona i-paclitaxel yendalo kunye ne-semi-synthetic paclitaxel zihluke kancinane kwisakhiwo sekhemikhali, ulwakhiwo lwazo olungundoqo luyafana, kwaye zombini ziyi-alkaloids ye-diterpenoid.

Umsebenzi webhayoloji kunye nokusebenza kakuhle

I-paclitaxel yendalo: Kwinkqubo yonyango, i-paclitaxel yendalo ibonakaliswe ukuba inefuthe elibalulekileyo lonyango kwiintlobo ezahlukeneyo zomhlaza, kubandakanywa umhlaza webele, umhlaza wesibeleko, umhlaza wentloko kunye nentamo, kunye nomhlaza wemiphunga. ye-tubulin kunye nokutshabalalisa inethiwekhi ye-microtubule yeseli, ngaloo ndlela inqanda ukwanda kweeseli kunye nokubangela i-apoptosis yeeseli zomhlaza.

I-Semi-synthetic paclitaxel:I-Semi-synthetic paclitaxel iyafana nokusebenza kwi-paclitaxel yendalo kwaye inomsebenzi obalulekileyo we-anticancer.Imveliso yobuninzi ye-semi-synthetic paclitaxel inokunyusa ukunikezelwa kwekliniki kwaye ibonelele ngeendlela ezininzi zonyango kwizigulane ezinomhlaza.

Iziphumo ebezingalindelekanga ezinetyhefu

I-paclitaxel yendalo:Ityhefu ye-paclitaxel yendalo iphantsi, kodwa isenokubangela iziphumo ezibi, ezinje ngokuguquguquka, ukucinezelwa komongo wethambo kunye netyhefu yentliziyo.

I-Semi-synthetic paclitaxel:Iziphumo zecala ze-semi-synthetic paclitaxel zifana nezo ze-paclitaxel zendalo.Zombini zifuna amayeza anengqiqo ngokusekelwe kwiimeko zomntu kunye neengcebiso zogqirha ukunciphisa umngcipheko wokuphendula okubi.

Amathuba ophuhliso lwexesha elizayo

Ngenkqubela phambili eqhubekayo yesayensi kunye nobuchwepheshe, uphando lwe-paclitaxel luya nzulu. Kwixesha elizayo, izazinzulu ziya kusebenza ukufumana iindlela ezisebenzayo ze-paclitaxel synthesis ukuqhubela phambili nokuphucula inkqubo yokuvelisa kunye nokuphucula ukusebenza kweklinikhi.Ngexesha elifanayo, kunye uphuhliso lobuchwepheshe obuvelayo obufana nobunjineli bemfuza kunye nonyango lweeseli, izicwangciso zonyango ezilungiselelwe wena ze-paclitaxel nazo ziyakwenzeka, ngaloo ndlela kubonelelwa izigulana ezinomhlaza ngeendlela ezichanekileyo nezisebenzayo zonyango.

Ukuqukumbela

Zombinipaclitaxel yendalokwayei-semi-synthetic paclitaxelNangona imvelaphi yabo kunye neendlela zokulungiselela zihlukile, babelana ngokufana kwisakhiwo sekhemikhali, umsebenzi webhayoloji kunye ne-pharmacodynamics.Imveliso enkulu ye-semi-synthetic paclitaxel inokunyusa ukunikezelwa kwekliniki, ngelixa i-paclitaxel yendalo ine Kwizifundo zexesha elizayo, izazinzulu ziya kuqhubeka nokuphonononga iindlela zebhayoloji zokwenza kunye neendawo zokusetyenziswa kwe-paclitaxel ukuzisa ithemba lonyango ngakumbi kwizigulana ezinomhlaza.

Qaphela:Iinzuzo ezinokubakho kunye nezicelo ezichazwe kweli nqaku zithathwe kuncwadi olupapashiweyo.